Tópicos em Biologia Tumoral Aplicada à Oncologia Veterinária

Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental

Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental da UNIP é nota 5 na CAPES
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O câncer apresenta-se como importante problema na saúde única, exibindo elevada morbidade e mortalidade em todo o mundo. Sua incidência tem crescido nos animais de companhia, em particular em cães e gatos, associado à maior sobrevida em animais domiciliados. Em paralelo, o conhecimento da biologia do processo cresce exponencialmente nas últimas décadas, em particular atrelado ao avanço da biologia molecular. Neste contexto, a disciplina visa abordar elementos relevantes da biologia tumoral, salientando aspectos de oncologia comparada, dentro de um enfoque celular e molecular, destacando-se:
  • Epidemiologia das neoplasias
  • Oncologia comparada
  • Conceito, classificação e diferenças entre neoplasias benignas e malignas, protocolos de graduação neoplásica
  • Princípios de diagnóstico oncológico: cito e histopatologia
  • Genética e epigenética no câncer
  • "Hallmarks of cancer"
  • Microambiente tumoral: imunidade, fibroplasia e vasculogênese tumoral (significado biológico, contexto molecular, padrões de organização, marcadores e quantificação)
  • Mecanismos de disseminação de tumores
Bibliografia:
AVALLONE, G., RASOTTO, R., CHAMBERS, J.K., MILLER, A.D., BEHLING-KELLY, E., MONTI, P., BERLATO, D., VALENTI, P., ROCCABIANCA, P. Review of Histological Grading Systems in Veterinary Medicine. Veterinary Pathology, 58:809-828, 2021.
BIFFI, G., TUVESON, D.A. Diversity and Biology of Cancer-Associated Fibroblasts. Physiol Rev. 2021 Jan 1;101(1):147-176. doi: 10.1152/physrev.00048.2019.
BROWN, J.S., AMEND, S.R., AUSTIN, R.H., GATENBY, R.A., HAMMARLUND, E.U., PIENTA, K.J. Updating the Definition of Cancer. Mol Cancer Res. 2023 Nov 1;21(11):1142-1147. doi: 10.1158/1541-7786.MCR-23-0411.
CEREZO-ECHEVARRIA, A., GRASSINGER, J.M., BEITZINGER, C., KLOPFLEISCH, R., AUPPERLE-LELLBACH, H. Evaluating the Histologic Grade of Digital Squamous Cell Carcinomas in Dogs with Dark and Light Haircoat-A Comparative Study of the Invasive Front and Tumor Cell Budding Systems. Vet Sci. 2020 Dec 30;8(1):3. doi: 10.3390/vetsci8010003.
DARWICHE, N. Epigenetic mechanisms and the hallmarks of cancer: an intimate affair. Am J Cancer Res. 2020 Jul 1;10(7):1954-1978.
DAS, V., BHATTACHARYA, S., CHIKKAPUTTAIAH, C., HAZRA, S., PAL, M. The basics of epithelial - mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective. Journal of Cell Physiology, 1-21, 2018.
DASGUPTA, A., NOMURA, M., SHUCK, R., YUSTEIN, J. Cancer's Achilles' Heel: Apoptosis and Necroptosis to the Rescue. Int J Mol Sci. 2016 Dec 23;18(1):23. doi: 10.3390/ijms18010023.
DOMINGUEZ, C., DAVID, J.M., PALENA, C. Epithelial-mesenchymal transition and inflammation at the site of the primary tumor. Semin Cancer Biol. 2017 Dec;47:177-184. doi: 10.1016/j.semcancer.2017.08.002.
ENDO, H., INOUE, M. Dormancy in cancer. Cancer Sci. 2019 Feb;110(2):474-480. doi: 10.1111/cas.13917.
ESTALLER, A., KESSLER, M., WEHEREND, A., HIRSCHBERGER, J., NEUMANN, S. Utility of Serum Ki-67 as a Marker for Malignancy in Dogs. Animals (Basel). May 14; 1263, 2022. https://doi.org/10.3390/ani12101263.
FURUSAWA, Y., TAKAHASHI, M., SHIMA-SAWA, M., HATAI, H., MIYOSHI, N., YAMATO, O., YABUKI, A. Immunocytochemical evaluation of epithelial-mesenchymal transition in epithelial tumors of dogs and cats. Journal of Veterinary Medicine Science. Sep 3, 1363-1368, 2021. https://doi.org/10.1292/jvms.21-0021.
HANAHAN, D., MONJE, M. Cancer hallmarks intersect with neuroscience in the tumor microenvironment. Cancer Cell. 2023 Mar 13;41(3):573-580. doi: 10.1016/j.ccell.2023.02.012.
HANAHAN, D., WEINBERG, R.A. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013.
HANAHAN, D., WEINBERG, R.A. The hallmarks of cancer. Cell. 2000 Jan 7;100(1):57-70. doi: 10.1016/s0092-8674(00)81683-9.
HAO, Y., BAKER, D., TEN DIJKE, P. TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis. Int J Mol Sci. 2019 Jun 5;20(11):2767. doi: 10.3390/ijms20112767.
KANWAL, R., GUPTA, K., GUPTA, S. Cancer epigenetics: an introduction. Methods Mol Biol. 2015;1238:3-25. doi: 10.1007/978-1-4939-1804-1_1.
KOK, V.C., YU, C.C. Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development. Int J Nanomedicine. 2020 Oct 19;15:8019-8036. doi: 10.2147/IJN.S272378.
LIU, Q., ZHANG, H., JIANG, X., QIAN, C., LIU, Z., LUO, D. Factors involved in cancer metastasis: a better understanding to "seed and soil" hypothesis. Mol Cancer. 2017 Dec 2;16(1):176. doi: 10.1186/s12943-017-0742-4.
NAGAMINE, E., HIRAYAMA, K., MATSUDA, K., OKAMOTO, M., OHMACHI, T., UCHIDA, K., KADOSAWA, T., TANIYAMA, H. Invasive front grading and epithelial mesenchymal transition in canine oral and cutaneous squamous cell carcinomas. Veterinary Pathology, 54 p.783-791, 2017.
PARK, D., SAHAI, E., RULLAN, A. SnapShot: Cancer-Associated Fibroblasts. Cell. 2020 Apr 16;181(2):486-486.e1. doi: 10.1016/j.cell.2020.03.013.
PLACKE, T., KOPP, H.G., SALIH, H.R. The wolf in sheep's clothing: Platelet-derived "pseudo self" impairs cancer cell "missing self" recognition by NK cells. Oncoimmunology. 2012 Jul 1;1(4):557-559. doi: 10.4161/onci.19367.
RAMOS-VARA, J.A. Principles and Methods of Immunohistochemistry. Methods Mol Biol. 2017;1641:115-128. doi: 10.1007/978-1-4939-7172-5_5.
RODRIGUES, P.C., SAWAZAKI-CALONE, I., ERVOLINO, O.C., SOARES, M.C.C., DOURADO, M.R., CERVIGNE, N.K., MIGUE, M.C., FERREIRA, C.A., LAMBERT, D.W., GRANER, E., SILVA, S.D., JAMALI, M.A.A., LEME, A.F.P., SALO, T.A., COLETTA, R.D. Fascin promotes migration and invasion and is a prognostic marker for oral squamous cell carcinoma. Oncotarget, 74736-74754, 2017.
SABRKHANY, S., KUIJPERS, MJE., OUDER EGBRINK, MGA., GRIFFIOEN, AW. Platelets as messengers of early-stage cancer. Cancer Metastasis Rev. 2021 Jun;40(2):563-573. doi: 10.1007/s10555-021-09956-4.
SENGA, S.S., GROSE, R.P. Hallmarks of cancer-the new testament. Open Biol. 2021 Jan;11(1):200358. doi: 10.1098/rsob.200358.
SHIBUE, T., WEINBERG, R.A. Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin Cancer Biol. 2011 Apr;21(2):99-106. doi: 10.1016/j.semcancer.2010.12.003.
SLEEMAN, J.P., CHRISTOFORI, G., FODDE, R., COLLARD, J.G., BERX, G., DECRANE, C., RÜEGG, C. Concepts of metastasis in flux: the stromal progression model. Semin Cancer Biol. 2012 Jun;22(3):174-86. doi: 10.1016/j.semcancer.2012.02.007.
SOARES, M., MADEIRA, S., CORREIA, J., PELETEIRO, M., CARDOSO, F., FERREIRA, F. Molecular based subtyping of feline mammary carcinomas and clinicopathological characterization. Breast. 2016 Jun;27:44-51. doi: 10.1016/j.breast.2016.02.016.
WALCHER, L., KISTENMACHER, A.K., SUO, H., KITTE, R., DLUCEZEK, S., STRAUSS, A., BLAUDSZUN, A.R., YEVSA, T., FRICKE, S., KOSSATZ-BOEHLERT, U. Cancer Stem Cells-Origins and Biomarkers: Perspectives for Targeted Personalized Therapies. Front Immunol. 2020 Aug 7;11:1280. doi: 10.3389/fimmu.2020.01280.
WEINBERG, R.A. A biologia do câncer, Porto Alegre, Artmed, 2008, 864p.
ZHANG, T., SUO, C., ZHENG, C., ZHANG, H. Hypoxia and Metabolism in Metastasis. Adv Exp Med Biol. 2019;1136:87-95. doi: 10.1007/978-3-030-12734-3_6.