Sobre o curso

The Stricto Sensu Postgraduate Program linked to Veterinary Medicine at Universidade Paulista (UNIP) began in 2003 with the creation of the Master's Degree in Veterinary Immunopathology. In view of the growing demand for knowledge in the environmental area, especially with regard to the impact of environmental changes on the origin of diseases and illnesses in animal and human health, the Program began to incorporate new perspectives. Considering the multidisciplinary profile of the teaching staff and the public, in February 2012 CAPES requested and accepted a change in the Program's name to “Environmental and Experimental Pathology”. The new name included two areas that were little explored in the Stricto Sensu Postgraduate Programs in the area of Veterinary Medicine in Brazil: Environmental and Experimental Pathology, which are fundamental for training professionals trained to work in applied health sciences, in which Veterinary Medicine is included. The education and training of professionals are priorities for national technological and scientific progress.

Between 2003 and 2024, the PPG graduated 162 Masters and 82 Doctors. Considering 2005 as the year of the first Master's degree, the annual average was 8.1 graduates/year. For the PhD program, which was first formed in 2012, the average was 6.3 PhDs/year. The program has the potential to increase the flow of graduates, as demonstrated by the high number of applicants in the biannual selection processes. The Master's program receives between 22 and 30 candidates per selection, while the Doctorate program attracts around 12 to 18 applicants. One of the main challenges for new students is the financial issue. To mitigate this obstacle, the university offers 50% discounted scholarships and, for CAPES scholarship holders, full scholarships. As the Master's and Doctorate require full dedication and presence in the laboratories, many students need financial support, as maintaining a simultaneous employment relationship becomes difficult.

The Program seeks to train Masters and PhDs in the area of Environmental and Experimental Pathology, which stands out for its multidisciplinary and multiprofessional nature, reflected in both the students and the teaching staff, made up of specialists from various areas of knowledge. Multidisciplinarity is one of the fundamental pillars of the program, enabling the development of research in line with social, environmental and market demands. The challenges faced go beyond theoretical content and require training that connects academic knowledge to professional reality. In this way, the Program encourages critical reflection and the application of innovative solutions to real problems, promoting the training of professionals committed to contemporary social and environmental issues.

Dean: Sandra Rejane Gomes Miessa
Vice-Dean Office of Graduate Studies and Research: Prof. Dr. Marina da Camino Ancona Lopez Soligo
Research and Graduate Studies Coordination: Prof. Dr. Marina da Camino Ancona Lopez Soligo
Stricto Sensu Postgraduate Secretary: Vera Lúcia Carlos Maia
Coordination: Prof. Dr. Maria Anete Lallo
Vice-Coordination: Prof. Dr. Ivana Barbosa Suffredini
Telephone: +55 11 5586-4171
E-mail: pgveterinaria@unip.br

The Program

A graduate student in the GP-EEP has formation in different areas of the Health, Agrarian, and Biological Sciences, which allows a multidisciplinary training that supports the development of a critical, current, innovative, and humanistic formation in the area of Environmental and Experimental Pathology under the light of the constant social demands. The interdisciplinary profile of the Collegiate, together with the development of basic and applied research, allows the translation of scientific knowledge to a critical and transversal view to find solutions to problems related to One Health.

Audience

Professionals trained in Health, Agrarian, and Biological Sciences, such as veterinarians, nurses, biomedical doctors, pharmacists, physiotherapists, physical education professionals, biologists, chemists, physicians, nutritionists, and related fields. 

Assessment Area: Veterinary Medicine

Area of Concentration: Environmental and Experimental Pathology

Involves the ecological study of diseases, focusing on the concepts of environmental health and One Health. The elements that potentially affect health and diseases caused by pathogens and xenobiotics introduced into the environment by human action are considered. The studies developed aim to expand knowledge and understand not only the diagnosis of pathological conditions that involve interaction with the environment, but also the search for models of corrective or mitigating interventions, contributing to the sustainability of the planet.

Translational and Integrated Pathology

It involves studies focused on identifying and characterizing the etiopathogenesis of diseases of veterinary interest, revealing the connection between multiple factors, with an emphasis on environmental factors. This line of research is based on the One Health approach.

Ecotoxicology and Therapeutic Innovations

It addresses the understanding of environmental problems and their repercussions on animal health and welfare, as well as the proposal of mitigating tools, including innovative methods and products whose benefit goes beyond clinical improvement by generating a positive impact on the ecosystem that permeates the treated populations.

The objectives of the PPG-PAE are based on excellence in scientific development and the training of qualified personnel to solve problems in the field of veterinary medicine in the coming years.

It also aims to integrate Universidade Paulista (UNIP) with local, regional, national and global communities, through national and international partnerships, exchanges and associations with other academic institutions, companies, public bodies and the third sector, expanding opportunities for collaboration and social impact.

To this end, the generation of new scientific knowledge that results in social and economic benefits and the improvement of teaching, with the development of new teaching-learning methodologies, research that expands knowledge and technological innovation, didactic-scientific articulation for undergraduate, secondary and elementary school teaching, integration with undergraduate courses to awaken vocations and talents for scientific production.

Mission

The mission of the Postgraduate Program in Environmental and Experimental Pathology (PPG-PAE) is to train teachers and researchers in the areas of Veterinary Medicine, Health and the Environment, enabling multidisciplinary training and the generation of critical, innovative and humanistic knowledge, in line with the demands of society.

Vision

Consolidate the PAE program and Paulista University's participation in national and international research focused on One Health. The training of Masters and Doctors in Veterinary Medicine in the context of Environmental and Experimental Pathology has an organically multidisciplinary character that allows for the development of basic research projects with rapid application in the productive sector and a positive socio-environmental impact, by preparing graduates to work on different work fronts, academic or otherwise, guaranteeing a high technical and scientific level.

Organizational Values

Ethics, inclusion, innovation and creativity, sustainability, environmental responsibility, transparency, self-criticism, solidarity and national and international cooperation.

The PPG's strategic planning is aligned with the university's Institutional Development Plan (IDP) (https://sistemasead.unip.br/controlepolo/Arquivos_Xf432mkerd12/PDI-2008-2017-reformulação-UNIP-Interativa-2011.pdf), which stands out with regard to institutional postgraduate teaching policies, which have been continually adapted to meet the demands of a constantly evolving academic and professional world, with the aim of guaranteeing academic excellence, fostering innovative research, and preparing students for the challenges of the global job market.

Alignment of short-, medium- and long-term goals in line with strategic planning

The PPG-PAE is drawing up a new 10-year strategic plan for the period from 2025 to 2035. Below are the points highlighted by the self-assessment that are included in the new plan:

A) Evaluating and Adapting Subject Content to the Current Student Profile
Goal: Carry out a more in-depth qualitative and quantitative analysis to understand the causes of the decline in interest in the content of each subject. Revise the curriculum to make the subjects more dynamic and aligned with the new needs of the students, without losing the essence of the training proposed by the program.
Action: Using an electronic form, which will be made available by the PPG secretariat, students will evaluate the subjects as soon as they are finished. The results will be presented to the PPG Board for discussion and identification of possible weaknesses, with a view to aligning the curriculum with changes in the student profile and market demands. Incorporate new teaching methodologies, such as problem-based learning (PBL) and digital technologies, to attract students with more diverse and up-to-date profiles.
Timeframe: 2025-2035

B) Strengthening Support for Participation in Scientific Events
Goal: To increase institutional support for participation in scientific events such as conferences, workshops and symposiums.
Action: Publicize and expand the institution's and funding agencies' support for participation in scientific events, ensuring that students and teachers have more opportunities to engage in events relevant to their area of research.
Timeframe: 2025-2035

C) Expanding Support and Mentoring in Research Activities
Goal: Expand and improve research support and mentoring practices, especially in the preparation of projects and the execution of dissertations and theses. Improve academic writing skills and increase the quality of the texts produced.
Action: Develop an academic mentoring program involving not only supervisors, but also former students or professionals in the field, to assist with practical issues and help develop innovative research. Organize annual scientific writing workshops focused on dissertations, theses and articles, with an emphasis on structure, clarity and scientific argumentation, as well as specific methodologies for international publications.
Deadline: 2025-2030

D) Fostering Integration between Students, Teachers and the Academic Community
Goal: Continue to strengthen the relationship between students and advisors, with a focus on developing collaborative projects and academic exchanges. Improve communication about the benefits and opportunities offered by the program, especially in the post-pandemic context. Maintain and promote a harmonious and collaborative working environment, prioritizing healthy interpersonal relationships between staff, students and teachers.
Action: Create regular events and seminars to facilitate interaction between students, teachers and external researchers. In addition, invest in interdisciplinary research groups. Establish more efficient communication channels, such as digital platforms, informative emails and regular meetings, to keep students and teachers up to date on new funding opportunities, events and resources. Create collaborative initiatives, such as study groups, mentoring between students and community activities within the program, to strengthen the bonds of solidarity and mutual aid.
Timeframe: 2025-2035

E) Strengthen Autonomy and Cooperation among Students with Multidisciplinary Work
Goal: Encourage cooperation between peers, with a view to creating working groups that integrate across disciplines and projects, with a focus on collaboration.
Action: Form teams of students with diverse academic backgrounds to develop joint projects.
Timeframe: 2025-2035

F) Implement Training Programs on Inclusion and Diversity
Goal: To provide ongoing training for staff, students and teachers on topics such as social inclusion, empathy and interpersonal communication. Promote a more inclusive and diverse environment, with actions that take into account the different profiles of students and employees.
Action: Organize workshops and training courses for all members of the program, raising awareness of the importance of inclusion, respect for diversity and the creation of a collaborative environment. Create and apply inclusion policies to ensure the participation of under-represented groups in the graduate program. This could include implementing affirmative action and supporting students with disabilities and from different social and cultural backgrounds.
Timeframe: 2025-2035

G) Investing in Teaching Infrastructure and Technologies
Goal: Improve the graduate program's infrastructure to support the new needs of hybrid teaching and research development.
Action: Ensure that the program has access to up-to-date laboratories and technological resources to carry out cutting-edge research. In addition, invest in online learning platforms to complement face-to-face classes.
Timeframe: 2025-2030

H) Monitoring the Organizational Climate
Goal: To regularly monitor the postgraduate program's organizational climate to ensure that the atmosphere of collaboration and harmony is maintained.
Action: Conduct biannual or annual organizational climate surveys to identify possible tensions or emerging problems in the academic environment and propose proactive solutions.
Timeframe: 2025-2028

I) Increasing the Technical-Scientific-Social Impact of Scientific Productions
Goal: Promote scientific production with significant technical-scientific-social impact.
Action: Create an incentive program for students to develop research with a direct focus on solutions to social, environmental and public health problems. Social impact should be a criterion for assessing the quality of dissertations and theses.
Deadline: Start in 2025, with six-monthly monitoring

J) Intensifying Partnerships with Institutions of Social Relevance
Goal: To strengthen collaboration between academia and institutions that work directly with society.
Action: Formalize partnerships with NGOs, government bodies and social enterprises, allowing students to carry out applied research internships, with a focus on knowledge transfer and direct social impact.
Deadline: Start in 2025, with annual partnerships formalized

K) Stimulating the Development of Scientific and Technological Innovations
Goal: To increase the number of patents resulting from research in the PPG-PAE and facilitate the transformation of scientific innovations into products or services applicable to the market. Monitor the impact of innovations generated within the program, including patents, environmental recovery projects and new approaches to veterinary health.
Action: Create an innovation incentive program to support and guide students and teachers in the generation of new patents and technologies and establish partnerships with start-up incubators and technology companies so that students and teachers can collaborate in the development of applied research projects with commercialization potential. Create a system of innovation indicators, monitoring the number of patents, the application of innovative solutions and the social and environmental impact of the projects developed in the program.
Deadline: 2025, with annual monitoring reports

L) Fostering Interdisciplinary Research with a Focus on Unique Health and Sustainability
Goal: Encourage collaboration between different areas of knowledge to develop innovative solutions that address issues of veterinary health, sustainability and the environment. Increase the number of projects focused on the sustainable management of fauna and flora, with an emphasis on environmental recovery and the responsible use of natural resources.
Action: Create multidisciplinary research groups involving professionals from various fields (such as Veterinary Medicine, Biomedicine, Environmental Sciences and Engineering), with the aim of developing projects focused on unique health, sustainability and environmental recovery.
Deadline: Start in 2025, with annual project grants

In addition to the issues raised by the self-assessment, some actions could be taken to mitigate the weaknesses and threats indicated by the application of the SWOT Matrix:

Internationalization: Expanding strategic partnerships with international universities and institutions to increase the mobility of students and teachers, as well as seeking out programs to promote academic mobility and international cooperation agreements. Promote international events and academic conferences to strengthen international presence and attract new opportunities.

Low availability of scholarships / fees for master's students: Look for new sources of funding, such as partnerships with companies (expand the partnership with Toyota) and funding agencies (send projects to CNPq and Capes) to increase the supply of scholarships. Increase the number of institutional grants and seek support from international funds for higher education.

Low number of professors with research grants: Encourage professors to seek out research funding notices and create collaborative research groups to increase competitiveness in grant applications.

Restricted funding for publications: Seek partnerships with publishers and companies to fund scientific publications; - Encourage the use of open access journals that have reduced costs or are funded by development agencies.

Strengthening partnerships with other institutions: To consolidate the Minter and Dinter programs.

Low visibility of the activities carried out by students and teachers: Invest in communication and marketing strategies to publicize academic activities, such as publications on social media, institutional websites and partnerships with the media; - Organize events and seminars open to the public, increasing the visibility of the work carried out by students and teachers.

Few grants from private companies: Seek closer ties with the private sector, creating agreements and strategic partnerships to attract more grants; - Develop research projects applied to the private sector, which demonstrate the practical impact of academic activities and encourage business funding.

In summary, PPG-PAE has great potential for growth, but needs to strengthen areas such as funding, visibility and internationalization, taking advantage of external opportunities while working to overcome internal weaknesses. These are key points for drawing up the next plan.

The Environmental and Experimental Pathology Program has modernized laboratories and accessible infrastructure for People with Special Needs (PwSN), integrated with the Research and Technology Center (CPT) and the Biodiversity Research Center (NPBio). These spaces serve not only Graduate programs but also support Undergraduate activities, including scientific initiation and internships, while also hosting students and faculty from other national and international universities.

The CPT and NPBio operate at a new location in the Indianópolis Campus, sharing a combined area of approximately 1,070 m² that includes various laboratories, faculty and student rooms, a classroom, cafeteria, and rest area.

Research and Technology Center (CPT) includes:

1. Pathological Anatomy Laboratory:
   Specialized in histological processing, including histochemical and immunohistochemical techniques, working with biopsy, necropsy, or experimental materials.
2. Experimental Homeopathy Study Laboratory:
   Dedicated to basic research on dynamized inputs, including biological models with Artemia salina and automated production of homeopathic potencies from raw materials approved by ANVISA or MAPA.
3. Molecular and Cellular Biology Laboratory (biosafety level 2):
   Designed for advanced research in molecular and cellular biology, supporting techniques like nucleic acid amplification (PCR), gene expression analysis, and microbial cultivation.
   Equipment: Laminar flow hoods, thermocyclers, CO2 incubators, refrigerated centrifuges, ELISA readers, BOD incubators, microscopes.
   More information here
4. Cell Culture Laboratory:
   Dedicated to cell cultivation and analysis, divided into two rooms: one for non-infected cells and another for pathogen-exposed cells.
   Equipment: Laminar flow hood, centrifuge, CO2 incubator, inverted microscope.
   More information here
5. Cryopreservation Laboratory:
   For safe preservation of biological materials used in scientific research.
   Equipment: Two ultra-low freezers (-80°C), three liquid nitrogen tanks (-196°C).
6. Imaging Laboratory:
   For fluorescence microscopy, bright-field microscopy, and digital macroscopy records.
   Equipment: Specialized microscopy equipment.
7. Flow Cytometry Laboratory:
   Specialized in multiparametric analysis of suspended cells for immunophenotyping, apoptosis studies, and biomarker detection.
   Equipment: BD Accuri C6 flow cytometer.
   More information here
8. SPF Animal Facility and Fish Bioterium:
   Maintains rats, mice and zebrafish (Danio rerio) under Specific Pathogen Free conditions, with specialized rooms for surgery, necropsy, and ultrasonic vocalization studies.
   Equipment: Techniplast microisolators, Noldus-EthoVision system, surgical equipment.
   More information here

Biodiversity Research Center (NPBio) includes:

1. Herbarium:
   Officially registered as "HERBÁRIO UNIP" with the Brazilian Botanical Society, containing about 11,000 Amazonian plant specimens.
   More information here
2. Extraction Laboratory and Extract Library:
   Stores over 2,300 extracts from Amazonian, Atlantic Forest and Antarctic plants at -20°C.
   More information here
3. Microbiology Laboratory:
   Evaluates antimicrobial response of plant extracts against veterinary-relevant bacteria and fungi.
4. Antitumor Screening Laboratory:
   Assesses cytotoxic activity of extracts against malignant tumors cultured in vitro, following NCI standards.
   Funding: Partially funded by FAPESP (2019/12202-3, 2018/21278-0, 2017/03470-9).

Infrastructure and Team

The multi-user laboratories are supported by 8 dedicated staff members including lab managers, herbarium curator, and technicians who provide training, maintenance, and experimental support. Veterinary hospitals at UNIP's Anchieta, Campinas, Bauru and São José dos Campos campuses support PPG-PAE research, along with partnerships with Butantan Institute, UNIFESP, USP and others.

University Structure

UNIP provides modern infrastructure supporting graduate activities including:

1. Theory and seminar rooms: Air-conditioned with computers, multimedia projectors, and hybrid videoconferencing via Microsoft Teams.
2. Qualification and defense rooms: Two equipped rooms with videoconferencing capabilities.
3. Student and faculty rooms: With computers, high-speed internet and printing facilities.
4. Auditoriums: With capacities for 50, 150 and 600 people.
5. Graduate Studies Office: Administrative support for students and faculty.
6. Library: The Indianópolis Library offers specialized team, accessible infrastructure, and access to 1,720,314 volumes and online databases through CAPES Portal.
7. Computer labs: Equipped with 20 computers, printers, and statistical analysis software.

1. Prof. Dr. Anuska Marcelino Alvares-Saraiva
   a) Partnership: Prof. Dr. Rui Curi - Institute of Physical Activity and Sport Sciences - ICAFE / Cruzeiro do Sul University, Sao Paulo; Dr Sandra Coccuzzo Sampaio Vessoni - Pathophysiology Laboratory of the Butantan Institute, Sao Paulo and Dr. Diva Denelle Spadacci-Morena - Pathophysiology Laboratory of the Butantan Institute, Sao Paulo. Project involved: Insulin-producing B-1 lymphocytes as a therapeutic target in Type 1 Diabetes: In vitro and in vivo study
   b) Partnership: Prof. Dr. Rui Curi, Prof. Dr. Tania Cristina Pithon Curi, Prof. Dr. Renata Gorjao and Prof. Dr. Sandro Massao Hirabara - Institute of Physical Activity and Sport Sciences - ICAFE / Cruzeiro do Sul University, Sao Paulo. Project involved: Cellular and molecular mechanisms involved in insulin resistance and inflammation in obese Wistar and goto-kakizaki lean rats: Causes and associations with diet and exercise
   c) Partnership: Prof. Dr. Ronni Rômulo Novaes e Brito – Sao Camilo University Center, Sao Paulo and Prof. Dr. Patrícia Xander Batista - Institute of Environmental, Chemical and Pharmaceutical Sciences (ICAQF)/ Federal University of Sao Paulo, Campus Diadema. Project involved: Behavior of B-1 cells in mice subjected to sleep restriction

2. Prof. Dr. Eduardo Fernandes Bondan
   a) Partnership: Prof. Dr. Rosemari Otton - Laboratory of Natural Antioxidants - Cruzeiro do Sul University (Sao Paulo - SP). Project involved: Study of the morphological, oxidative and behavioral effects of the administration of doxorubicin associated with curcumin and resveratrol in Wistar rats
   b) Partnership: Transmission Electron Microscopy Laboratory, Department of Anatomy, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo (FMVZ – USP). Project involved: Ultrastructural study of glial cells Bothrops jararaca (Reptilia, Ofidia)
   c) Partnership: Dr. Marcelo Paes de Barros (Institute of Physical Activity and Sport Sciences - ICAFE / Cruzeiro do Sul University). Project involved: Study of oxidative parameters in the central nervous system of rats treated with doxorubicin
   d) Partnership: Dr. Miriam Oliveira Ribeiro (Laboratory of Neurobiology / Universidade Presbiteriana Mackenzie). Project involved: Induction of iodothyronine deiodinase after status epilepticus modifies hippocampal gene expression in male mice

3. Prof. Dr. Elizabeth Cristina Pérez Hurtado
   a) Partnership: Drs. Patricia Xander and Ana Claudia Torrecilhas. Department of Microbiology, Immunology and Parasitology Federal University of Sao Paulo and Institute of Environmental, Chemical and Pharmaceutical Sciences (ICAQF) Federal University of Sao Paulo, Campus Diadema. Project involved: In vivo evaluation of the influence of extracellular vesicles released by 4T1 cells on breast tumor development.
   b) Partnership: Prof. Dr. Diva Denelle Spadacci-Morena. Pathophysiology Laboratory, Instituto Butanta and Center for Biological and Health Sciences, Universidade Cruzeiro do Sul. Project involved: In vitro evaluation of the influence of extracellular vesicles released by melanoma cells on the metabolism of murine macrophages.
   c) Partnership: Prof. Dr. Ivone Mackowiak. Department of Pathology - FMVZ- USP. Project involved: In vitro evaluation of the effect of homeopathic preparations Phytolacca decandra on human breast adenocarcinoma cells.
   d) Partnership: Prof. Dr. Mario Cruz. Research Support Facility Center (CEFAP-USP). Project involved:study In vitro of the expression and epigenetic regulation of M-SEC protein in breast adenocarcinoma cells, after interactions with macrophages.
   e) Partnership: Prof. Dr. Carla Holandino. Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ). Projects involved: 1.evaluation In vitro of the effect of homeopathic preparations Viscum album on murine melanoma cells (B16F10). 2. Study of the effects in vivo of homeopathic preparations of Viscum album (L.) in the murine melanoma model

4. Prof. Dr. Ivana Barbosa Suffredini
   a) Partnership: Prof. Dr. Joao Henrique Ghilardi Lago – Center for Natural and Human Sciences – UFABC. Project involved: Screening of plant extracts with antifungal activity.
   b) Partnerships: Prof. Dr. Márcia Ortiz M. Marques – Agronomic Institute of Campinas; Prof. Dr. Marcos N. Eberlin – ThomSon Laboratory, UNICAMP Institute of Chemistry and UP Mackenzie. Project involved: Evaluation of essential oil components of Iryanthera polyneura.
   c) Partnerships: Prof. Dr. Jorge Flório – Veterinary Medicine USP; Prof. Dr. Cidéli P. Coelho – Santo Amaro University. Project involved: Study of behavioral changes in Luffa operculata in Wistar rats
   d) Partnerships: Prof. Dr. Paulo RH Moreno – Institute of Chemistry at USP. Project involved: Alkaloids and biological activities of Annona hypoglauca.
   e) Partnerships: Prof. Dr. Luiz Fernando L. Reis – Hospital Sírio Libanes; Prof. Dr. Riad N. Younes – Oswaldo Cruz German Hospital. Project involved: Chemical and biological study of Microplumeria anomalous.
   f) Partnerships: Prof. Dr. Cintia HC Saraceni, Prof. Dr. Maristela Dutra-Correia, Prof. Dr. Maristela Dutra-Correia. Dr. Luciano Dib, Prof. Dr. Élcio M. Giovani – PPG-Dentistry UNIP. Projects involved: Bacterial and biofilm analysis in dental materials.

5. Prof. Dr. José Guilherme Xavier
   a) Partnership: Prof. Dr. Cristina de O. Massoco S. Gomes – Department of Pathology – FMVZ-USP. Project involved: Microenvironment and tumor aggressiveness: cancer-associated fibroblasts (CAFs), pericytes and prognosis in canine oral melanoma
   b) Partnership: Prof. Dr. Ricardo de Francisco Strefezzi, Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering-USP. Projects involved: Tumor-extracellular matrix interaction in canine cutaneous mast cell tumors; Characterization of genes related to apoptosis in canine cutaneous mast cell tumors and their value as a prognostic indicator
   c) Partnership: Prof. Dr. Primavera Borelli – Department of Clinical and Toxicological Analysis at FCF-USP. Projects involved: Evaluation of the hematopoietic endosteal niche of mice subjected to protein malnutrition

6. Prof. Dr. Leoni V. Bonamin
   a) Partnership: Prof. Joao Sarkis Yunes, FURGS, RS, Brazil; Prof. Igor Jerman - Bion Institute, Slovenia; Prof. Steven Cartwright - Diagnox, Oxford, UK. Project involved: Effects of isotherapeutics on the experimental intoxication of Artemia salina
   b) Partnership: Prof. Carla Holandino - Federal University of Rio de Janeiro; Prof. Steven Cartwright - Diagnox, Oxford, UK. Project involved: Physicochemical characterization of homeopathic medicines.
   c) Partnership: Prof. Silvia Waisse - Pontifical Catholic University of Sao Paulo. Project involved: International book publishing: Transdisciplinarity and Translationality in High Dilutions Research - Signal and Image GIRI series. Cambridge Scholars Publishing, Cambridge, UK. 2019.
   d) Partnership: Dr. Sergio Ribeiro - CIRAT / IPWS (International Panel on Water Structure), Brasilia, Brazil; Prof. Gerald Pollack, University of Washington in Seattle, USA. Project involved: Editing of a special issue of the journal Water - A multidisciplinary research journal - Commemorative edition for the 9th World Water Forum in Dakar, March 2022, with the objective of disseminating advanced knowledge about water at different structural levels.

7. Prof. Dr. Maria Anete Lallo
   a) Partnership: Instituto Butantan, Laboratory of Physiopathology, to perform transmission electron microscopy, Dr. Diva Denelle Spadacci-Morena. Project involved: Morphodifferentiation of the Organ of Gene of engorged ticks Amblyomma sculptum (Acari: Ixodidae)
   b) Partnership: Disciplines of Cell Biology and Immunology, Department of Microbiology and Immunology – Federal University of Sao Paulo, Prof. Dr. Alexandre Keller. Project involved: Role of NKT cells in encephalitozoonosis
   c) Partnership: Department of Micro, Immuno-Parasitology Federal University of Sao Paulo and Institute of Environmental, Chemical and Pharmaceutical Sciences (ICAQF) Federal University of Sao Paulo campus Diadema, Prof. Dr. Patricia Xander Batista. Project involved: Influence of B-1 cells or their extracellular vesicles on the activity of effector immune cells in microsporidiosis

8. Prof. Dr. Maria Martha Bernardi
   a) Partnership: Dr. Claudia Madalena Mori - Department of Pathology - FMVZ / University of Sao Paulo. Project involved: Phenotypic characterization of ENU-induced and spontaneous mutant mice
   b) Partnership: Sandra Maria Miraglia Valdeolivas - Escola Paulista de Medicina – EPM/UNIFESP Department: Morphology and Genetics. Project involved: Effects of moderate chronic stress, induced from peripuberty, and escitalopram treatment on the reproductive parameters of adult rats.
   c) Partnership: Dr. Miriam Oliveira Ribeiro (Laboratory of Neurobiology / Universidade Presbiteriana Mackenzie). Projects Involved: 1. Hyperlipidic diet increases fat weight and induces glucose intolerance in Balb-c-XID mice. 2. Role of environmental enrichment in the recovery of memory impairment in ?3-ARKO mice

9. Prof. Dr. Rodrigo Augusto da Silva
   a) Partnership: Prof. Dr. Willian Fernando Zambuzzi, LaBio – Laboratory of Bioassays and Cell Dynamics, Universidade Estadual Paulista, UNESP. Project: Osteogenic markers and epigenetic reprogramming during the phenotypic transition of vascular smooth muscle: from contraction to calcification.
   b) Partnership: Prof. Dr. Alexandra Latini, LABOX – Laboratory of Bioenergetics and Oxidative Stress, Federal University of Santa Catarina, UFSC. Project: Metabolic, biochemical and epigenetic characterization of the inflammatory response in the Central Nervous System.
   c) Partnership: Prof. Dr. Alex Rafacho, LIDoC – Chronic Disease Research Laboratory, Federal University of Santa Catarina, UFSC. Project: Impact of exposure to organophosphate pesticides on gestation, post-term, fetuses and adult offspring of rats.
   d) Partnership: Prof. Dr. Alexander Birbrair, Birbrair Lab, Federal University of Minas Gerais, UFMG. Project: Evaluation of the impact of sensory nerve activation in the modulation of epigenetic mechanisms in the tumor microenvironment: Implications for tumor development and progression.
   e) Partnership: Prof. Dr. Valério Garrone Barauna, Center for Physiological Sciences, Federal University of Espírito Santo, UFES. Project: Pathophysiological Mechanisms and the Search for Biomarkers in Septic Patients: role of cfDNA methylation. 

10. Prof. Dr. Thiago Berti Kirsten
    a) Partnership: Prof. Dr. Luciano Freitas Felicio - Laboratory of Reproductive Behavior Neurobiology, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo. Project involved: Autism and dopaminergic system - analysis of sex differences, molecular and behavioral aspects.
    b) Partnership: Prof. Dr. Claudia Madalena Mori - Laboratory of Animal Models, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo. Project involved: Studies with spontaneous and chemically induced mutant mice.
    c) Partnership: Prof. Dr. Helenice de Souza Spinosa – Department of Pathology, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo. Project involved: Exposure of dams to fluoxetine during lactation disturbs maternal behavior but had no effect on the offspring behavior.

11. Prof. Dr. Welber Senten Smith
    a) Partnership: Prof. Dr. Miguel Petrere Jr – Postgraduate Program in Aquatic Ecology and Fisheries – UFPA. Project involved: Reproductive biology of migratory fish from the Sorocaba river basin as subsidies for the maintenance of free stretches of rivers.

Methodology adopted for self-evaluation:

In order to achieve the goals proposed in the strategic planning of the PPG in Environmental and Experimental Pathology (PPG-PAE), a Self-Assessment Committee (CPA) was set up, made up of 8 teachers, 2 students, 2 laboratory technicians and 1 administrative technician. The main objective of the self-assessment is to analyze the academic and administrative management of the PPG-PAE at UNIP in order to promote the adjustments and improvements needed to achieve academic, scientific and social excellence. The graduate profile of the PPG is structured according to the guidelines of the Institutional Development Plan (PDI) of Universidade Paulista (UNIP) and contributes to the training of masters and doctors according to some priority areas outlined for Veterinary Medicine in Brazil for the coming years.

The self-evaluation process was conducted by the PPG's CPA in accordance with the guidelines established in the Self-Evaluation Project (available at https://unip.br/cursos/pos_graduacao/strictosensu/patologia/apresentacao.aspx), which dialogues with the University's self-evaluation project, conducted by Unip's CPA (available at https://unip.br/universidade/cpa.aspx).

Data collection for the self-evaluation involved the following instruments:

a) Biannual survey of faculty and student/graduates' production: this is done by consulting their Lattes CVs, with surveys/tables of their intellectual production, serving to monitor and guide the achievement of the goals required by CAPES in the four-yearly evaluations.
b) Documentary analysis: institutional and national documents are analyzed based on the indicators defined for each item established by CAPES, the Vice-Rectory of Graduate Studies and Research and the Program.
c) Semi-structured individual or group interviews: these are carried out with teaching staff, the coordinator, graduates, students and administrative staff;
d) Application of questionnaires: to collect data and information with students, teachers, coordinators and technical-administrative representatives. The questions covered the items established by CAPES and the PPG-PAE (Google Forms Platform).
e) Seminars: Research and Self-Assessment Seminars are held annually and can be used for data collection, as well as for socializing the results of the self-assessment and discussing Strategic Planning.
f) Regular meetings: In order to achieve the objectives proposed for the Self-Evaluation process, regular meetings of the CPA and the PPG Collegiate take place periodically.