Tópicos em Biologia Tumoral Aplicada à Oncologia Veterinária

Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental

Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental da UNIP é nota 5 na CAPES
Siga o Programa nas redes sociais:
Ementa:
O câncer apresenta-se como importante problema na saúde única, exibindo elevada morbidade e mortalidade em todo o mundo. Sua incidência tem crescido nos animais de companhia, em particular em cães e gatos, associado à maior sobrevida em animais domiciliados. Em paralelo, o conhecimento da biologia do processo cresce exponencialmente nas últimas décadas, em particular atrelado ao avanço da biologia molecular. Neste contexto, a disciplina visa abordar elementos relevantes da biologia tumoral, salientando aspectos de oncologia comparada, dentro de um enfoque celular e molecular, destacando-se:
  • Epidemiologia das neoplasias
  • Oncologia comparada
  • Conceito, classificação e diferenças entre neoplasias benignas e malignas, protocolos de graduação neoplásica
  • Princípios de diagnóstico oncológico: cito e histopatologia
  • Genética e epigenética no câncer
  • "Hallmarks of cancer"
  • Microambiente tumoral: imunidade, fibroplasia e vasculogênese tumoral (significado biológico, contexto molecular, padrões de organização, marcadores e quantificação)
  • Mecanismos de disseminação de tumores
Bibliografia:
  • Avallone, G., Rasotto, R., Chambers, J.K., Miller, A.D., Behling-Kelly, E., Monti, P., Berlato, D., Valenti, P., Roccabianca, P. 2021. Review of Histological Grading Systems in Veterinary Medicine. Veterinary Pathology, 58:809-828.
  • Biffi G, Tuveson DA. Diversity and Biology of Cancer-Associated Fibroblasts. Physiol Rev. 2021 Jan 1;101(1):147-176. doi: 10.1152/physrev.00048.2019. Epub 2020 May 28. PMID: 32466724; PMCID: PMC7864232.
  • Brown JS, Amend SR, Austin RH, Gatenby RA, Hammarlund EU, Pienta KJ. Updating the Definition of Cancer. Mol Cancer Res. 2023 Nov 1;21(11):1142-1147. doi: 10.1158/1541-7786.MCR-23-0411. PMID: 37409952; PMCID: PMC10618731.
  • Cerezo-Echevarria A, Grassinger JM, Beitzinger C, Klopfleisch R, Aupperle-Lellbach H. Evaluating the Histologic Grade of Digital Squamous Cell Carcinomas in Dogs with Dark and Light Haircoat-A Comparative Study of the Invasive Front and Tumor Cell Budding Systems. Vet Sci. 2020 Dec 30;8(1):3. doi: 10.3390/vetsci8010003. PMID: 33396709; PMCID: PMC7824281.
  • Darwiche N. Epigenetic mechanisms and the hallmarks of cancer: an intimate affair. Am J Cancer Res. 2020 Jul 1;10(7):1954-1978. PMID: 32774995; PMCID: PMC7407342.
  • Das, V., Bhattacharya, S., Chikkaputtaiah, C., Hazra, S., Pal, M. 2018. The basics of epithelial - mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective. Journal of Cell Physiology, 1-21.
  • Dasgupta A, Nomura M, Shuck R, Yustein J. Cancer's Achilles' Heel: Apoptosis and Necroptosis to the Rescue. Int J Mol Sci. 2016 Dec 23;18(1):23. doi: 10.3390/ijms18010023. PMID: 28025559; PMCID: PMC5297658.
  • Dominguez C, David JM, Palena C. Epithelial-mesenchymal transition and inflammation at the site of the primary tumor. Semin Cancer Biol. 2017 Dec;47:177-184. doi: 10.1016/j.semcancer.2017.08.002. Epub 2017 Aug 18. PMID: 28823497; PMCID: PMC5698091.
  • Endo H, Inoue M. Dormancy in cancer. Cancer Sci. 2019 Feb;110(2):474-480. doi: 10.1111/cas.13917. Epub 2019 Jan 11. PMID: 30575231; PMCID: PMC6361606.
  • Estaller, A., Kessler, M., Wehrend, A., Hirschberger, J., Neumann, S. 2022. Utility of Serum Ki-67 as a Marker for Malignancy in Dogs. Animals (Basel). May 14; 1263. https://doi.org/10.3390/ani12101263
  • Furusawa, Y., Takahashi, M., Shima-Sawa, M., Hatai, H., MiyoshiI, N., Yamato, O., Yabuki, A. 2021. Immunocytochemical evaluation of epithelial-mesenchymal transition in epithelial tumors of dogs and cats. Journal of Veterinary Medicine Science. Sep 3, 1363-1368. https://doi.org/10.1292/jvms.21-0021
  • Hanahan D, Monje M. Cancer hallmarks intersect with neuroscience in the tumor microenvironment. Cancer Cell. 2023 Mar 13;41(3):573-580. doi: 10.1016/j.ccell.2023.02.012. PMID: 36917953; PMCID: PMC10202656.
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. PMID: 21376230.
  • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000 Jan 7;100(1):57-70. doi: 10.1016/s0092-8674(00)81683-9. PMID: 10647931.
  • Hao Y, Baker D, Ten Dijke P. TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis. Int J Mol Sci. 2019 Jun 5;20(11):2767. doi: 10.3390/ijms20112767. PMID: 31195692; PMCID: PMC6600375.
  • Kanwal R, Gupta K, Gupta S. Cancer epigenetics: an introduction. Methods Mol Biol. 2015;1238:3-25. doi: 10.1007/978-1-4939-1804-1_1. PMID: 25421652.
  • Kok VC, Yu CC. Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development. Int J Nanomedicine. 2020 Oct 19;15:8019-8036. doi: 10.2147/IJN.S272378. PMID: 33116515; PMCID: PMC7585279.
  • Liu Q, Zhang H, Jiang X, Qian C, Liu Z, Luo D. Factors involved in cancer metastasis: a better understanding to "seed and soil" hypothesis. Mol Cancer. 2017 Dec 2;16(1):176. doi: 10.1186/s12943-017-0742-4. PMID: 29197379; PMCID: PMC5712107.
  • Nagamine, E., Hirayama, K., Matsuda, K., Okamoto, M., Ohmachi, T., Uchida, k., Kadosawa, T., Taniyama, H. 2017. Invasive front grading and epithelial mesenchymal transition in canine oral and cutaneous squamous cell carcinomas. Veterinary Pathology, 54 p.783-791.
  • Park D, Sahai E, Rullan A. SnapShot: Cancer-Associated Fibroblasts. Cell. 2020 Apr 16;181(2):486-486.e1. doi: 10.1016/j.cell.2020.03.013. PMID: 32302576.
  • Placke T, Kopp HG, Salih HR. The wolf in sheep's clothing: Platelet-derived "pseudo self" impairs cancer cell "missing self" recognition by NK cells. Oncoimmunology. 2012 Jul 1;1(4):557-559. doi: 10.4161/onci.19367. PMID: 22754786; PMCID: PMC3382889.
  • Ramos-Vara JA. Principles and Methods of Immunohistochemistry. Methods Mol Biol. 2017;1641:115-128. doi: 10.1007/978-1-4939-7172-5_5. PMID: 28748460.
  • Rodrigues, P.C., Sawazaki-Calone, I., Ervolino O. C., Soares, M. C.C., Dourado, M.R., Cervigne, N.K., Migue, M.C., Ferreira, C. A., Lambert, D.W., Graner, E., Silva, S.D., Jamali, M.A.A., Leme, A.F.P., Salo, T.A., Coletta,R.D. 2017. Fascin promotes migration and invasion and is a prognostic marker for oral squamous cell carcinoma. Oncotarget., 74736-74754.
  • Sabrkhany S, Kuijpers MJE, Oude Egbrink MGA, Griffioen AW. Platelets as messengers of early-stage cancer. Cancer Metastasis Rev. 2021 Jun;40(2):563-573. doi: 10.1007/s10555-021-09956-4. Epub 2021 Feb 26. PMID: 33634328; PMCID: PMC8213673.
  • Senga SS, Grose RP. Hallmarks of cancer-the new testament. Open Biol. 2021 Jan;11(1):200358. doi: 10.1098/rsob.200358. Epub 2021 Jan 20. PMID: 33465324; PMCID: PMC7881179.
  • Shibue T, Weinberg RA. Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin Cancer Biol. 2011 Apr;21(2):99-106. doi: 10.1016/j.semcancer.2010.12.003. Epub 2010 Dec 9. PMID: 21145969.
  • Sleeman JP, Christofori G, Fodde R, Collard JG, Berx G, Decraene C, Rüegg C. Concepts of metastasis in flux: the stromal progression model. Semin Cancer Biol. 2012 Jun;22(3):174-86. doi: 10.1016/j.semcancer.2012.02.007. Epub 2012 Feb 21. PMID: 22374376.
  • Soares M, Madeira S, Correia J, Peleteiro M, Cardoso F, Ferreira F. Molecular based subtyping of feline mammary carcinomas and clinicopathological characterization. Breast. 2016 Jun;27:44-51. doi: 10.1016/j.breast.2016.02.016. Epub 2016 Mar 21. PMID: 27212699.
  • Walcher L, Kistenmacher AK, Suo H, Kitte R, Dluczek S, Strauß A, Blaudszun AR, Yevsa T, Fricke S, Kossatz-Boehlert U. Cancer Stem Cells-Origins and Biomarkers: Perspectives for Targeted Personalized Therapies. Front Immunol. 2020 Aug 7;11:1280. doi: 10.3389/fimmu.2020.01280. PMID: 32849491; PMCID: PMC7426526.
  • Weinberg, RA. A biologia do câncer, Porto Alegre, Artmed, 2008, 864p.
  • Zhang T, Suo C, Zheng C, Zhang H. Hypoxia and Metabolism in Metastasis. Adv Exp Med Biol. 2019;1136:87-95. doi: 10.1007/978-3-030-12734-3_6. PMID: 31201718.