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Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental

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Maria Anete Lallo

Prof. Dr. Maria Anete Lallo

Coordinator and Full Professor

Stricto Sensu Graduate Program in Environmental and Experimental Pathology
Universidade Paulista

maria.lallo@docente.unip.br

Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

Curriculum Vitae

Veterinary Physician graduated from the Londrina State University, specialized in Clinics and Surgery of Small Animals by the Faculty of Veterinary Medicine and Animal Science of USP, where she got a Master’s and Doctorate in Applied Experimental Epidemiology at Zoonosis. Productivity Fellow 2, belongs to the CNPq research groups in Clinical and Infectious Diseases (UNIP) and Biology of Cell Differentiation and Transformation: Modulation by Endogenous and Exogenous factors. Her research theme covers opportunistic and emerging protozoa, involving epidemiological, pathogenic and immunological aspects, particularly in the study of microsporidiosis in mammals, with emphasis on the parasite-host relationship. Since the Postdoctoral stage with the project "The role of B-1 cells in experimental infection by E. cuniculi in mice", a new research theme involving innate immunity, B-1 cells and cell death in Microsporidioses was introduced.

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Research Lines and Groups

Disciplines

  • Seminários de Projetos
  • Epidemiologia Aplicada ao Ambiente e à Saúde
  • Seminários da Semana Científica

Highlighted publications

Spadacci-Morena DD et al. 2021. Encephalitozoon cuniculi takes advantage of efferocytosis to evade the immune response. PLoS One, 16:e0247658. DOI: https://doi.org/10.1371/journal.pone.0247658

Moura MLC et al. 2019. Cyclophosphamide Treatment Mimics Sub-Lethal Infections With Encephalitozoon intestinalis in Immunocompromised Individuals. Front Microbiol, 10:2205-2205. DOI: https://doi.org/10.3389/fmicb.2019.02205

Pereira A et al. 2019. B-1 cell-mediated modulation of M1 macrophage profile can ameliorate microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. PLoS Negl Trop Dis, 13: e0007674. DOI: https://doi.org/10.1371/journal.pntd.0007674

Langanke dos Santos D et al. 2018. B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis. Microbes infect, 20:196-204. DOI: https://doi.org/10.1016/j.micinf.2017.11.004

Dos Santos MF. 2018. Morphodifferentiation of Gené’s organ in engorged Amblyomma sculptum Berlese, 1888 female ticks (Acari: Ixodidae). Ticks Tick Borne Dis, 9:519-525. DOI: https://doi.org/10.1016/j.ttbdis.2018.01.004

Ivana Barbosa Suffredini

Prof. Dr. Ivana Barbosa Suffredini

Vice-Coordinator and Full Professor

Stricto Sensu Graduate Program in Environmental and Experimental Pathology
Universidade Paulista

ivana.suffredini@docente.unip.br

Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

Curriculum Vitae

Pharmacist, Master’s and Ph.D. by USP-SP, Post-Doctorate in Toxicology, by Universidade Paulista. Responsible for the Center for Research in Biodiversity-UNIP. CNPq Productivity Fellow 2. Member of the Ethics Committee on the Use of Animals. She works in Pharmacognosy, Pharmacology, and Toxicology of Medicinal Plants and Microbiology, with the themes Evaluation of Antitumor, Antimicrobial, Antioxidant, Toxicity and Behavioral Changes of plant extracts and essential oils, with interest focused on Veterinary and Human Medicine. She is one of the leading researchers of the Rio Negro Project. Leader of the Research Group Biological, Pharmacological and Toxicological Activities of Natural Products, researcher of the Neuropsychopharmacology Experimental and Environmental, Therapeutic and Curative Schemes Proposed and Recommended in the Treatment of Oral Diseases Group and Briotech Group, which studies Antarctic bryophytes.

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Research Lines and Groups

Disciplines

  • Produtos Naturais em Ciências da Saúde
  • Bioética e Metodologia Científica
  • Tópicos Especiais Aplicados à Educação
  • Seminários de Projetos
  • Seminários da Semana Científica

Highlighted publications

Frias HV et al. 2021. Vertical exposition to Luffa operculata extract deregulates behavior and hypothalamus neurotransmitters in juvenile rats. J. Ethnopharmacology, 264:113265. DOI: https://doi.org/10.1016/j.jep.2020.113265

Martins ER et al. 2019. Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach. PLoSOne. 14(11):e0224406. DOI: https://doi.org/10.1371/journal.pone.0224406

Martins ER et al. 2019. Interference of Seasonal Variation on the Antimicrobial and Cytotoxic Activities of the Essential Oils from the Leaves of Iryanthera polyneura in the Amazon Rain Forest. Chemistry & Biodiversity. 16(10):e1900374. DOI: https://doi.org/10.1002/cbdv.201900374

Alves CS et al. 2018. Luffa Operculata Fruit Aqueous Extract Induces Motor Impairments, Anxiety-Like Behavior, And Testis Damage In Rats. Journal of Ethnopharmacology, 222:52-60. DOI: https://doi.org/10.1016/j.jep.2018.04.044

Suffredini IB et al. 2017. Mice Behavioral Phenotype Changes after Administration of Anani (Symphonia globulifera, Clusiaceae), an Alternative Latin American and African Medicine. Pharmacognosy Magazine, 13:617-626. DOI: https://doi.org/10.4103/pm.pm_168_17

Alessandra Castro

Prof. Dr. Alessandra Marnie Martins Gomes de Castro

Full Professor

Stricto Sensu Graduate Program in Environmental and Experimental Pathology
Universidade Paulista

alessandra.castro8@docente.unip.br

Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

Curriculum Vitae

Veterinarian by University of Marília (UNIMAR) (1992 - 1997). Master's degree in Animal Science by Paulista State University (UNESP), Ilha Solteira (1997 - 2000) and PhD in Experimental Epidemiology Applied to Zoonoses by Faculty of Veterinary Medicine and Animal Science of the University of São Paulo (FMVZ/USP) (2001 - 2005). Post doctor degree by Faculty of Veterinary Medicine and Animal Science at the University of São Paulo (2008 - 2013) and at the Veterinary Diagnostic and Production Animal Medicine at Iowa State University (2019 - 2020). Coordinated two FAPESP projects - Young Researcher (2009 - 2013) and a regular one (2016 - 2018). Experience in Genetics, with emphasis on Molecular Genetics of Viruses. Reviewer of national and international scientific journals. Works mainly on the following topics: microbiology (emphasis on bacteria and viruses); Vaccine development and laboratory diagnosis for infectious diseases. Since 2016, has been participated in vaccine development projects for swine at Iowa State University.

Médico Veterinario graduado en la Universidad de Marília (UNIMAR) (1992 - 1997). Maestría en Ciencia Animal de la UNESP, Universidade Estadual Paulista, Campus de Ilha Solteira (1997 - 2000) y Doctorado en Epidemiología Experimental Aplicada a las Zoonosis de la Facultad de Medicina Veterinaria y Ciencia Animal de la Universidad de São Paulo (FMVZ/USP) (2001 - 2005). Realizó estudios de Postdoctorado en la Facultad de Medicina Veterinaria y Ciencia Animal de la Universidad de São Paulo (2008 - 2013) y en Medicina Veterinaria de Diagnóstico y Producción Animal en la Universidad Estatal de Iowa (2019 - 2020). Coordinó el proyecto Joven Investigador (2009 - 2013) y el proyecto regular FAPESP (2016 - 2018). Experiencia en Genética, con énfasis en Genética Molecular de Virus. Revisor de revistas científicas nacionales e internacionales. Trabaja principalmente en los siguientes temas: microbiología (énfasis en bacterias y virus); desarrollo de vacunas y diagnóstico de laboratorio para enfermedades infecciosas. Desde 2016, ha participado en proyectos de desarrollo de vacunas porcinas en la Universidad Estatal de Iowa.

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  • Research lines and Groups

    Clininfec - Clínica e Doenças Infecciosas Veterinárias

    Disciplines

    Epidemiologia Aplicada ao Ambiente e à Saúde (colaboradora)
    Epigenética básica I (colaboradora)
    Emergência e reemergencia das doenças infecciosas no mundo globalizado (responsável)

    Highlighted publications

    KARUPPANNAN, ANBU K.; DE CASTRO, ALESSANDRA MARNIE M. G.; OPRIESSNIG, TANJA. Recent Advances in Veterinary Diagnostic Virology. Advanced Techniques in Diagnostic Microbiology. 3ed.: Springer International Publishing, 2018, p. 317-344. DOI: 10.1007/978-3-319-95111-9_14
    CORTEZ, A.; METORIMA, C.S.; MIYAGI, S.A.T.; SOUSA, A.O.; PEYSER, A.V.; CASTRO, A.M.M.G.; BALDISSERI JR, F.A.; SOUZA FILHO, A.F.; BRANDÃO, P.E.; HEINEMANN, M.B. High genetic diversity of hepatitis E virus in swine in São Paulo State, Brazil. ARQUIVO BRASILEIRO DE MEDICINA VETERINÁRIA E ZOOTECNIA (ONLINE), v. 73, p. 1237-1242, 2021. https://doi.org/10.1590/1678-4162-12203
    OPRIESSNIG, TANJA; KARUPPANNAN, ANBU K.; CASTRO, ALESSANDRA M.M.G.; XIAO, CHAO-TING. Porcine circoviruses: current status, knowledge gaps and challenges. VIRUS RESEARCH, v. 286, p. 198044, 2020. https://doi.org/10.1016/j.virusres.2020.198044
    OPRIESSNIG, TANJA; CASTRO, ALESSANDRA M.M.G.; KARUPPANAN, ANBU K.; GAUGER, PHILLIP C.; HALBUR, PATRICK G.; MATZINGER, SHANNON R.; MENG, XIANG-JIN. A Porcine circovirus type 2b (PCV2b)-based experimental vaccine is effective in the PCV2b-Mycoplasma hyopneumoniae coinfection pig model. VACCINE, v. 37, p. 6688-6695, 2019. https://doi.org/10.1016/j.vaccine.2019.09.029
    OPRIESSNIG, TANJA; GAUGER, PHILLIP C.; GERBER, PRISCILLA F.; CASTRO, ALESSANDRA M. M. G.; SHEN, HUIGANG; MURPHY, LITA; DIGARD, PAUL; HALBUR, PATRICK G.; XIA, MING; JIANG, XI; TAN, MING. Comparison of the efficacy of a commercial inactivated influenza A/H1N1/pdm09 virus (pH1N1) vaccine and two experimental M2e-based vaccines against pH1N1 challenge in the growing pig model. PLoS One, v. 13, p. e0191739, 2018. https://doi.org/10.1371/journal.pone.0191739

    Anuska Marcelino Alvares Saraiva

    Prof. Dr. Anuska Marcelino Alvares Saraiva

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    anuska.saraiva@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Anuska obtained her bachelor’s degree in Biological Sciences (2007) from UNESP´s Bauru School of Sciences, São Paulo State University, Brazil. and completed her Ph.D. in the Department of Microbiology, Immunology and Parasitology at Paulista Medical School, Federal University of São Paulo in 2013. She concluded postdoctoral fellow at Health Science Institute, Paulista University, Brazil (2013-2017) and at Institute of Sciences of Physical Activity and Health, Cruzeiro do Sul University, Brazil collaborating with Physiopathology Laboratory at Butantan Institute (2019-2021). In 2015, she described the regulatory role of B-1 lymphocytes in the diabetes experimental model and the ability of these cells to produce insulin. Currently, she studies cellular therapy using metabolic reprogramming of insulin-producing B-1 cells in vitro for their therapeutic use in Type 1 Diabetes. Her research focuses on B-1 cells' regulatory role in the diabetes model and their interactions with effector and regulatory T lymphocytes in the context of autoimmunity and metabolic diseases. She also contributes to several studies focusing on host-parasite relationship, Immune response in infections and immune response in tumoral models.

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    Research Lines and Groups

    Disciplines

    • Da cultura de Células à Terapia Celular: Fundamentos e Avanços

    Highlighted publications

    Alvares-Saraiva AM et al. 2015. B-1 cells produce insulin and abrogate experimental streptozotocin-induced diabetes. Eur J Immunol, 45:1452-1461. DOI: https://doi.org/10.1002/eji.201445409

    Da Costa LFV et al. 2016. B-1 cell decreases susceptibility to encephalitozoonosis in mice. Immunobiology, 222:218-227. DOI: https://doi.org/10.1016/j.imbio.2016.09.018

    Francisco Neto A et al. 2017. Diabetes mellitus increases the susceptibility to encephalitozoonosis in mice. PLoS One, 12:e0186954. DOI: https://doi.org/10.1371/journal.pone.0186954

    Langanke dos Santos D et al. 2018. B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis. Microbes infect, 20:196-204. DOI: https://doi.org/10.1016/j.micinf.2017.11.004

    Pereira A et al. 2019. B-1 cell-mediated modulation of M1 macrophage profile can ameliorate microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. PLoS Negl Trop Dis, 13:e0007674. DOI: https://doi.org/10.1371/journal.pntd.0007674

    Eduardo Fernandes Bondan

    Prof. Dr. Eduardo Fernandes Bondan

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    eduardo.bondan@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Veterinary physician from the Federal University of Pelotas (1985), M.Sc in Veterinary Medicine from the Federal University of Pelotas (1989), Specialist in Physiological Sciences from the University of Rio Grande (1993), Ph.D. in Experimental and Comparative Pathology from the University of São Paulo (1997) and postdoctoral researcher from the Universidade Paulista (2014). He has experience in morphology, focusing on neurobiology, acting on the following topics: glial cells, demyelination and remyelination, chemobrain (or post-chemotherapy cognitive dysfunction), neurodegenerative diseases, infectious and parasitic diseases related to the nervous system. Participates in the CNPq research groups of Experimental and Environmental Neuropsychopharmacology and Biological, Pharmacological and Toxicological Activities of Natural Products, both at UNIP. He is also a CNPq Productivity Fellow Teacher (level 1D).

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    Research Lines and Groups

    Disciplines

    • Métodos de Investigação em Neuropatologia

    Highlighted publications

    Cardoso CV et al. 2020. Chemobrain in rats: Behavioral, morphological, oxidative and inflammatory effects of doxorubicin administration. Behav Brain Res, 378:112233. DOI: https://doi.org/10.1016/j.bbr.2019.112233

    Molina J et al. 2020. Reduced astrocytic expression of GFAP in the offspring of female rats that received hypercaloric diet. Nutr Neurosci, 23:411-421. DOI: https://doi.org/10.1080/1028415X.2018.1512783

    Ogassawara TB et al. 2018. Food deprivation in F0 generation and hypercaloric diet in F1 generation reduce F2 generation astrogliosis in several brain areas after immune challenge. Int J Dev Neurosci, 64:29-37. DOI: https://doi.org/10.1016/j.ijdevneu.2017.06.003

    Nascimento BPP et al. 2018. Induction of type 2 iodothyronine deiodinase after status epilepticus modifies hippocampal gene expression in male mice. Endocrinology, 159: 3090-3104. DOI: https://doi.org/10.1210/en.2018-00146

    Martins-Júnior JL et al., 2016. Propentofylline treatment on open field behavior in rats with focal ethidium bromide-induced demyelination in the ventral surface of the brainstem. Life Sci, 148:132-138. DOI: https://doi.org/10.1016/j.lfs.2016.02.028

    Elizabeth Cristina Perez Hurtado

    Prof. Dr. Elizabeth Cristina Perez Hurtado

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    elizabeth.hurtado@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Undergraduate as a Medical technologist at Universidad del Valle - Colombia (1994), Master in Science Applied to Pediatrics (2003), Ph.D. in Science at the Postgraduate Program in Microbiology and Immunology (2008) of the Federal University from São Paulo – Brazil (UNIFESP) and Post-doctor in tumor immunology (2011) by UNIFESP. Currently, she works as a full professor at the Graduate Program in Environmental and Experimental Pathology, being in charge of the Molecular and Cell Biology Laboratory of the Research Center at Universidade Paulista and working as a collaborating researcher in the Discipline of Immunology at UNIFESP. Her line of research encompasses the study of interactions between tumor cells and immune system components and their role in tumor formation and progression, besides the evaluation of the mechanisms of action of conventional and alternative anti-tumor drugs. She works in the areas of immunology, cell and molecular biology, transplants and microbiology, in the following topics: tumor immunology, tumor microenvironment, alternative therapies, extracellular vesicles, metabolism, immune response in infectious diseases caused by yeasts and parasites.  

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    Research Lines and Groups

    Disciplines

    • Técnicas biológicas em pesquisa
    • Imunorregulação
    • Seminários de Projetos
    • Seminários da Semana Científica

    Highlighted publications

    Pérez EC et al. 2008. B-1 lymphocytes increase metastatic behavior of melanoma cells through the extracellular signal-regulated kinase pathway. Cancer Sci, 99(5):920-928. DOI: https://doi.org/10.1111/j.1349-7006.2008.00776.x

    Staquicini FI et al. 2008. A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule/MUC18-dependent interaction: evidence from mice and humans. Cancer Res, 15;68(20):8419-8428. DOI: https://doi.org/10.1158/0008-5472.CAN-08-1242

    Perez EC et al. 2017. The axis IL-10/claudin-10 is implicated in the modulation of aggressiveness of melanoma cells by B-1 lymphocytes. PLoS One, 12(11):e0187333. DOI: https://doi.org/10.1371/journal.pone.0187333

    Almeida EB et al. 2019. A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment. Int J Mol Sci, 20(15):3765. DOI: https://doi.org/10.3390/ijms20153765

    Colhado Rodrigues BL et al. 2020. The Controversial Role of Autophagy in Tumor Development: A Systematic Review. Immunol Invest, 49(4):386-396. DOI: https://doi.org/10.1080/08820139.2019.1682600

    Giovani Bravin Peres

    Prof. Dr. Giovani Bravin Peres

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    giovani.peres@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Giovani Peres é professor nas áreas de Ciências da Saúde e entusiasta da Educação. É Bacharel em Ciências Biológicas - Modalidade Médica pela Universidade Federal de São Paulo (2009), Mestre (2012) e Doutor em Ciências (2016) pelo programa de pós-graduação em Biologia Molecular da mesma Universidade. Também é Especialista em Administração de Empresas pela Fundação Getúlio Vargas (2014). Atualmente é Professor Titular da Universidade Paulista (UNIP), no Programa de Pós-Graduação em Patologia Ambiental e Experimental (Medicina Veterinária) e do curso de Biomedicina. Possui experiência em: a) pesquisa acadêmica na área de Bioquímica e Biologia Molecular, com ênfase em Glicoconjugados; b) ensino, lecionando do Pré-Vestibular à Pós-Graduação, atuando também em cargos de Coordenação; c) gestão colaborativa e administração de empresas.

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    Research Lines and Groups

    Disciplines

    • Estatística Aplicada à Pesquisa I
    • Estatística Aplicada à Pesquisa II

    Highlighted publications

    Peres, GB et al. 2017. Impact of high glucose and AGEs on cultured kidney-derived cells. Effects on cell viability, lysosomal enzymes and effectors of cell signaling pathways. Biochimie, 135:137-148. DOI: http://dx.doi.org/10.1016/j.biochi.2017.02.004

    De Santana, FR et al. 2017. High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro. Cytokine, 92:33-47. DOI: http://dx.doi.org/10.1016/j.cyto.2017.01.004

    Siqueira, SA et al 2017. Interface between breast cancer cells and the tumor microenvironment using platelet-rich plasma to promote tumor angiogenesis - influence of platelets and fibrin bundles on the behavior of breast tumor cells. Oncotarget, 8:16851-16874. DOI: http://dx.doi.org/10.18632/oncotarget.15170

    Toricelli, M et al. 2013. Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. Mol Cancer, 12:22. DOI: http://dx.doi.org/10.1186/1476-4598-12-22

    Peres, GB et al. 2012. Lysosomal enzymes are decreased in the kidney of diabetic rats. Biochim Biophys Acta, 1832:85-95. DOI: http://dx.doi.org/10.1016/j.bbadis.2012.09.011

    José Guilherme Xavier

    Prof. Dr. José Guilherme Xavier

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    jose.xavier@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Veterinary Doctor from the University of São Paulo (1988), Residency in Veterinary Anatomic Pathology from the University of São Paulo (1991), Master (1993) and Doctor (1999) in Experimental and Comparative Pathology from the University of São Paulo, Specialist in Veterinary Pathology at ABPV. He is currently full professor at the Paulista University of São Paulo. He is advisor (master’s and doctoral level) at the Postgraduate Program in Environmental and Experimental Pathology at the Paulista University of São Paulo. Coordinates the research group "Biology of cell differentiation and transformation: modulation by endogenous and exogenous factors" - UNIP. He has experience in animal and comparative pathology, with an emphasis on diagnostic, prognostic and predictive markers in animal neoplasms; experimental and comparative oncology; veterinary surgical pathology; pathology of lymphohematopoietic organs.

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    Research Lines and Groups

    Disciplines

    • Tópicos em Biologia Tumoral

    Highlighted publications

    Yasumaru CC et al. 2021. Intratumoral T-Lymphocyte Subsets in Canine Oral Melanoma and Their Association With Clinical and Histopathological Parameters. Vet Pathol, 25:300985821999321. DOI: https://doi.org/10.1177/0300985821999321

    Nishiya AT et al. 2020. Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas. Toxins, 12(3):157. DOI: https://doi.org/10.3390/toxins12030157

    Daniel J et al. 2019. Intratumoral collagen index predicts mortality and survival in canine cutaneous mast cell tumours. Vet Dermatol, 30(2):162-e48. DOI: https://doi.org/10.1111/vde.12726

    Barra CN et al. 2018. Apoptotic intrinsic pathway proteins predict survival in canine cutaneous mast cell tumours. Vet Comp Oncol, 16(1):E38-E44. DOI: https://doi.org/10.1111/vco.12330

    Joselevitch JA et al. 2018. Nanog Expression and Proliferation Indices in Canine Cutaneous Mast Cell Tumors. Vet Pathol, 55(6):849-852. DOI: https://doi.org/10.1177/0300985818789470

    Leoni Villano Bonamin

    Prof. Dr. Leoni Villano Bonamin

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    leoni.bonamin@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Veterinary Doctor (USP, 1987), Master (1990) and Doctor (1995) in Experimental and Comparative Pathology from the University of São Paulo (USP), with a Doctorate in Sandwich at ENVL - France (1992-1993) and Post-Doctorate in Environmental Pathology and Experimental by UNIP (2015). Research Productivity Scholarship by CNPq level 2 between 2011-2014 and 2018-2021. President (2002-2008) and Vice President (2008-2014) of GIRI (Groupe International de Recherche sur l'Infinitésimal). Deputy-Editor of the journal "Homeopathy – The Journal of the Faculty of Homeopathy – London." Member of the Editorial Board of the International Journal of High Dilution Research (IJHDR) and the "Water – A multidisciplinary research journal." Member of the Homeopathy Research Institute ( HRI, UK) since 2013 and the International Panel on Water Structure (IPWS) since 2020. Coordinator of the project "Map of Evidence in Homeopathy" (2021), organized by CABSIN - Brazilian Academic Consortium of Integrative Health, with Fiocruz–RJ's support.

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    Research Lines and Groups

    Disciplines

    • Susceptibilidade e complexidade na abordagem da saúde única
    • Tópicos Especiais Aplicados à Educação

    Highlighted publications

    Bonamin LV et al. 2019. Transdisciplinarity and Translationality in High Dilution Research. 1. ed. Cambridge: Cambridge Scholars Publishing, 277pp. Link: https://www.cambridgescholars.com/product/978-1-5275-3252-6

    Endler, PC et al. 2010. Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study. Homeopathy, 99:25-36. DOI: https://doi.org/10.1016/j.homp.2009.11.008

    Santana FR et al. 2017. High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro. Cytokine, 92: 33-47. DOI: https://doi.org/10.1016/j.cyto.2017.01.004

    Aparicio AC et al. 2020. Interaction between solvatochromic dyes and water sampled from a natural source treated with high dilutions of phosphorus. Homeopathy, 109:126-132. DOI: https://doi.org/10.1055/s-0039-3400255

    Bonamin LV. 2020. Characterization of Antimonium crudum Activity Using Solvatochromic Dyes. Homeopathy, 109:79-86. DOI: https://doi.org/10.1055/s-0039-1697000

    Maria Martha Bernardi

    Prof. Dr. Maria Martha Bernardi

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    maria.bernardi@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Degree in Biological Sciences from the University of São Paulo, Master's and Doctorate in Physiology, concentration area Pharmacology from the Institute of Biomedical Sciences of the University of São Paulo and Post-doctorate at the Department of Pharmacology at the Institute of Biomedical Sciences-USP and the Faculty of Veterinary Medicine and Animal Science-USP. Senior Visiting Professor (CAPES) at the Federal University of ABC. Linked to the graduates Program in Environmental and Experimental Pathology of Veterinary Medicine,Universidade Paulista. Has experience in Pharmacology, Toxicology, and Neurosciences. The most important line of research is involved with Developmental Toxicology and Neurosciences and Behavior. Studies the changes promoted in the perinatal period by immune system modulators, drugs, heavy metals, pesticides, and endocrine disruptors to investigate the behavioral, endocrine, epigenetic, molecular aspects, and the development of animal models of mental disorders. Since 2016, has been part of the Zebrafish Platform, which aims to disseminate, study and establish models in this fish for studies in the most varied areas of science. Is the editor of the book Pharmacology Applied to Veterinary Medicine and has several chapters in books on Pharmacology and Veterinary Toxicology and a book on Animal Behavior. Leader-coordinator of the Research-CNPq Experimental and Environmental Neuropsychopharmacology group.

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    Highlighted publications

    Bernardi et al. 2021. Overweight induced by hypernutrition in juvenile rats dysregulates the central monoamines in the adult age. Psychol Neurosci, 14:34-48. DOI: https://doi.org/10.1037/pne0000204

    Mendes-Lima et al. 2020. Prenatal LPS induces sickness behaviour and decreases maternal and predatory behaviours after an LPS challenge. Int J Neurosci, 130(8):804-816. DOI: https://doi.org/10.1080/00207454.2019.1706505

    Reis-Silva et al. 2019. Stress resilience evidenced by grooming behaviour and dopamine levels in male mice selected for high and low immobility using the tail suspension test. Eur J Neurosci, 50(6):2942-2954. DOI: https://doi.org/10.1111/ejn.14409

    Cordeiro et al. 2018. Ivermectin acute administration impaired the spermatogenesis and spermiogenesis of adult rats. Res Vet Sci, 117:178-186. DOI: https://doi.org/10.1016/j.rvsc.2017.12.013

    Lima et al. 2017.Acute lipopolysaccharide switches the selection of maternal behavior to predatory behavior in female rats. Neuroimmunomodulation, 24(1):1-10. DOI: https://doi.org/10.1159/000469711

    Rodrigo Augusto da Silva

    Prof. Dr. Rodrigo Augusto da Silva

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    rodrigo.silva3@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Graduated in Biology from the University of the Sacred Heart (2005) and Ph.D. by the Functional and Molecular Biology program at Unicamp (2011). Performed Post-doctoral internships at the Faculty of Dentistry of Piracicaba/UNICAMP (2011), at the Federal University of Santa Catarina/UFSC (2013) and at the Biosciences Institute of Botucatu/IBB (2016) with sandwich periods at the Electronic Microscopy Center of UNC, Córdoba/AR; at the Laboratory for Gastroenterology and Hepatology, ERASMUS Medical Center, Rotterdam/NL and at the Centro de Investigaciones Biomédicas y Regulación del Genome at Universidad Andres Bello, Santiago/CL. Leader of the research group Epigenetic mechanisms applied to the transcriptional control of CNPq, scientific consultant for international journals and member of the Internal Biosafety Research Commission at Universidade Paulista / UNIP (CIBio). Have experience in Biochemistry and Molecular Biology, with an emphasis on cell signaling and epigenetic regulation mechanisms. His researches is mainly focused on the study of epigenetic mechanisms applied to transcriptional control. Working mainly in the fields of Neuroepigenetics applied to aging, differentiation of mesenchymal cells and Maternal and Fetal Epigenetics.

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    Research Lines and Groups

    Disciplines

    • Epigenética Básica I
    • Epigenética Básica II

    Highlighted publications

    Assis RIF et al. 2021. Non-coding RNAs repressive role in post-transcriptional processing of RUNX2 during the acquisition of the osteogenic phenotype of periodontal ligament mesenchymal stem cells. Dev Biol. Feb, 470:37-48. DOI: https://doi.org/10.1016/j.ydbio.2020.10.012

    da Silva RA et al. 2019. HOXA cluster gene expression during osteoblast differentiation involves epigenetic control. Bone, 125:74-86. DOI: https://doi.org/10.1016/j.bone.2019.04.026

    da Silva RA et al. 2019. Osteogenic gene markers are epigenetically reprogrammed during contractile-to-calcifying vascular smooth muscle cell phenotype transition. Cell Signal, 66:109458. DOI: https://doi.org/10.1016/j.cellsig.2019.109458

    da Silva RA et al.2019. Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation. Mol Neurobiol, 56:1539-1557. DOI: https://doi.org/10.1007/s12035-018-1175-9

    da Silva RA et al. 2019. Laminar shear stress-provoked cytoskeletal changes are mediated by epigenetic reprogramming of TIMP1 in human primary smooth muscle cells. J Cell Physiol, 234:6382-6396. DOI: https://doi.org/10.1002/jcp.27374

    Thiago Berti Kirsten

    Prof. Dr. Thiago Berti Kirsten

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    thiago.kirsten@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Bachelor's and Licentiate degrees in Biological Sciences. Master (MSc) and Ph.D. in Sciences (FMVZ-USP). Postdoctoral research fellow; FAPESP grants. Currently Full Professor and Scientist Researcher of the Stricto Sensu Program in Environmental and Experimental Pathology, Paulista University (score CAPES 5). Leader of the Psychoneuroimmunology Laboratory and of a CNPq Research Group: Experimental and Environmental Neuropsychopharmacology. Advisor, Scientific Consultant, and Reviewer of an ethics committee on the use of animals and of international scientific journals. Medical writer of 55+ scientific papers published in international scientific journals, in addition to book chapters and didactic/instructional books. His Ph.D. thesis has won the 'Capes Thesis Award' (best Thesis), competing with a thesis from all over the country. Research expertise in scientific/therapeutical areas of Psychoneuroimmunology, Neuropsychopharmacology, Neuroscience, Animal Behavior, Experimental Models, Mental Health, Neuropsychiatric Disorders, Perinatal Studies, Microbiology, Pharmacology, Toxicology, and Molecular Biology.

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    Research Lines and Groups

    Disciplines

    • Modelos Experimentais em Comportamento de Animais de Laboratório
    • Tópicos Especiais Aplicados à Educação

    Highlighted publications

    Kirsten TB et al. 2020. Zinc, but not paracetamol, prevents depressive-like behavior and sickness behavior, and inhibits interferon-gamma and astrogliosis in rats. Brain Behav Immun, 87:489-497. DOI: https://doi.org/10.1016/j.bbi.2020.01.019

    Parisi DP et al. 2019. Therapeutical doses of ivermectin and its association with stress disrupt motor and social behaviors of juvenile rats and serotonergic and dopaminergic systems. Res Vet Sci, 124: 149-157. DOI: https://doi.org/10.1016/j.rvsc.2019.03.009

    Leme E et al. 2018. Billings reservoir water used for human consumption presents microbiological contaminants and induces both behavior impairments and astrogliosis in zebrafish. Ecotoxicol Environ Saf, 161:364-373. DOI: https://doi.org/10.1016/j.ecoenv.2018.06.009

    Kirsten TB et al. 2018. Pioglitazone abolishes autistic-like behaviors via the IL-6 pathway. PLoS One, 13:e0197060. DOI: https://doi.org/10.1371/journal.pone.0197060

    Kirsten TB et al. 2015. Lipopolysaccharide Exposure Induces Maternal Hypozincemia, and Prenatal Zinc Treatment Prevents Autistic-Like Behaviors and Disturbances in the Striatal Dopaminergic and mTOR Systems of Offspring. Plos One, 10:e0134565. DOI: https://doi.org/10.1371/journal.pone.0134565

    Welber Senteio Smith

    Prof. Dr. Welber Senteio Smith

    Full Professor

    Stricto Sensu Graduate Program in Environmental and Experimental Pathology
    Universidade Paulista

    welber.smith@docente.unip.br

    Street Dr. Bacelar, 1212, São Paulo, SP 04026-002, Brazil

    Curriculum Vitae

    Graduated in Biological Sciences at the Pontifical Catholic University of São Paulo, Master’s, and Doctorate in Environmental Engineering Sciences from the University of São Paulo. Scholarship holder of the Santander Ibero-American Program for Young Teachers and Researchers. Research Internship at Department of Life Sciences, University of Coimbra. Full Professor, Biological Sciences - UNIP. Advisor and researcher at the Postgraduate Program in Environmental and Experimental Pathology at Universidade Paulista - UNIP. Advisor and researcher at the Postgraduate Program in Aquaculture and Fisheries at Fisheries Institute/APTA. He belongs to the CNPq research groups in Structural and Functional Ecology of Ecosystems (leader); Biodiversity, Biogeography, and Conservation. His line of research covers ecosystem ecology, limnology, freshwater fish ecology, physical, chemical, and biological processes in inland aquatic systems, as subsidies for recovery and management, aiming at the sustainable development of water resources. Assessment of environmental impacts on aquatic ecosystems (water and sediment) through bioassays using aquatic organisms of different trophic levels.

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    Research Lines and Groups

    Disciplines

    • Fundamentals and Current Affairs in Environmental Sciences

    Highlighted publications

    TONELLA, L. H.; SMITH, W. S. NEOTROPICAL FRESHWATER FISH: a dataset of occurrence and abundance of freshwater fish in theNeotropics. ECOLOGY., 2021.

    PORTELLA, A. C.; ARSENTALES, A. D.; CAVALLARI, D. E.; SMITH, W. S. Efeito da sazonalidade na reprodução de peixes Characiformes em um rio Neotropical. IHERINGIA SERIEZOOLOGIA. , v.111, p.1 - 9, 2021.

    Biodiversidade do Município de Sorocaba: Atualização e subsídios para a sua conservação. Sorocaba: WELBER SENTEIO SMITH , 2020, v.1. p.364.

    Biodiversidade no Campus: Unip Sorocaba. Sorocaba: WELBER SENTEIO SMITH, 2020, v.1. p.192.

    SILVA, FABIO LEANDRO DA; STEFANI, MARTA SEVERINO; SMITH, WELBER SENTEIO; SCHIAVONE, DANIELE CRISTINA; CUNHA-SANTINO, MARCELA BIANCHESSI DA; BIANCHINI JR, IRINEU An applied ecological approach for the assessment of anthropogenic disturbances in urban wetlands and the contributor river. Ecological Complexity. , v.43, p.100852 - , 2020.

    CNPq Productivity Fellow Professors

    Prof. Dr. Eduardo Fernandes Bondan
    Productivity Fellow 1D – Process# 303944/2019-6 (2020-2023), Title: Chemobrain in rats – Morphological, oxidative, inflammatory and behavioral studies after administration of doxorubicin chemoterapeutics in rats treated or not with curcumin or resveratrol

    Prof. Dr. Ivana Barbosa Suffredini
    Productivity Fellow 2 – Process# 304699/2018-7. (2018-2021). Title: The Brazilian biodiversity as a source of new Veterinarian medicines.

    Prof. Dr. Leoni Villano Bonamin
    Productivity Fellow 2 – Processo 304778/2017-6. (2018-2021). Title: Mechanisms involved in the antimonium high dilutions over the Leishmania (L) amazonensis in vitro infection. 

    Prof. Dr. Maria Anete Lallo
    Productivity Fellow 2 – Process# 303191/2019-8. (2020-2022). Title: Modulation of the M1 and M2 macrophages profiles in the Encephalitozoon cuniculi infection.

    Prof. Dr. Maria Martha Bernardi
    Productivity Fellow 1A – Process# 302401/2019-9. Title: Transgenerational effects of the paternal ivermectin rat exposition.

    Scientific Production

    Featured Articles

    • Alves Neto, A.F., Rocha, P.R.D., Pérez, E.C., Xavier, J.G., Peres, G.B., Spadacci-Morena, D.D., Alvares-Saraiva, A.M., Lallo, M.A. Diabetes mellitus increases the susceptibility to encephalitozoonosis in mice. PloSOne, 2017, DOI: https://doi.org/10.1371/journal.pone.0186954
    • Alves, C.S.; Frias, H.V.; Kirsten, T.B.; Cordeiro, F.; Bernardi, M.M.; Suffredini, I.B. Luffa operculata Fruit Aqueous Extract Induces Motor Impairments, Anxiety-Like Behavior, And Testis Damage In Rats. Journal of Ethnopharmacology, 2018, DOI: https://doi.org/10.1016/j.jep.2018.04.04;
    • Araujo, G. A.; Matta., E. C.; Lallo, M.A.; Machado, G.F.; Rocha, P.R.D.A.. Epicarditis in a cat caused by feline infectious peritonitis virus: case report. Arquivo Brasileiro De Medicina Veterinária E Zootecnia, 2020, DOI: https://doi.org/10.1590/1678-4162-11359
    • Cardoso, C.V.; Barros, M.P.; Bachi, A.L.; Bernardi, M.M.; Kirsten, T.B.; Martins, M.F.M.; Rocha, P.R.A.; Rodrigues, P.S.; Bondan, E.F. Chemobrain in rats: Behavioral, morphological, oxidative and inflammatory effects of doxorrubicin administration. Behavioural Brain Research, 2020, DOI: https://doi.org/10.1016/j.bbr.2019.112233, 2020
    • da Costa, L.F., Alvares-Saraiva, A.M., Rocha, P.R.D., Xavier, J.G., Pérez, E.C., Mariano, M.), Lallo, M.A. B-1 cell decreases susceptibility to encephalitozoonosis in mice. Immunobiology, 2017, DOI: https://doi.org/10.1016/j.imbio.2016.09.018
    • Dalboni LC, Nascimento KF, Konno FT, Alvares-Saraiva AM, Correia MSF, Bomfim MDC, Casarin RCV, Perez EC, Lallo MA, Peres GB, Laurenti MD, Benites NR, Buchi DF, Bonamin LV. High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro Cytokine, 2017, DOI: https://doi.org/10.1016/j.cyto.2017.01.004
    • Joaquim, A.O., Coelho, C.P., Motta, P.D., Felício, L.F., Bondan, E.F., Teodorov, E., Martins, M.F.M., Kirsten, T.B., Bonamin, L.V., Bernardi, M.M. Maternal food restriction in rats of the F0 generation increases retroperitoneal fat, the number and size of adipocytes and induces periventricular astrogliosis in female F1 and male F2 generations. Reproduction, Fertility and Development, 2017, DOI: https://doi.org/10.1071/RD15309
    • Kirsten, T.B.; Cabral, D.; Galvão, M.C.; Monteiro, R.; Bondan, E.F.; Bernardi, M.M. Zinc, but not paracetamol, prevents depressive-like behavior and sickness behavior, and inhibits interferon-gamma and astrogliosis in rats. Brain, Behavior and Immunity, 2020, DOI: https://doi.org/10.1016/j.bbi.2020.01.019
    • Leme, E.; Silva, E.P.; Rodrigues, P.S.; Silva, I.R.; Martins, M.F.M.; Bondan, E.F.; Bernardi, M.M.; Kirsten, T.B. Billings reservoir water used for human consumption presents microbiological contaminants and induces both behavior impairments and astrogliosis in zebrafish. Ecotoxicology and Environmental Safety, 2018, DOI: https://doi.org/10.1016/j.ecoenv.2018.06.009
    • Martins, E.R., Díaz IEC, Paciencia MLB, Fana, S.A., Morais D, Eberlin MN, Silva, J.S., Silveira, E.R., Barros, M.P., Suffredini IB. Interference of Seasonal Variation on the Antimicrobial and Cytotoxic Activities of the Essential Oils from the Leaves of Iryanthera polyneura in the Amazon Rain Forest. Chemistry & Biodiversity, 2019, DOI: https://doi.org/10.1002/cbdv.201900374
    • Martins, E.R.; Díaz, I.E.C.; Paciencia, M.L.B.; Frana, S.A.; Marques, M.O.M.; de Morais, D.R.; Eberlin, M.N.; Suffredini, I.B. Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach. PLoSOne , 2019, DOI: https://doi.org/10.1371/journal.pone.0224406
    • Molina, J.; Joaquim, A.; Bonamin, L.V.; Martins, M.F.M.; Kirsten, T.B.; Cardoso, C.V.; Bernardi, M.M.; Bondan, E.F. Reduced astrocytic expression of GFAP in the offspring of female rats that received hypercaloric diet. Nutritional Neuroscience , 2019, DOI: https://doi.org/10.1080/1028415X.2018.1512783
    • Moreira, R.T.F.; Lallo, M.A.; Saraiva, A.M.A.; Perez, E.C.; Konno, F.T.; Spadacci-Morena, D.D.; Coutinho, S.D. Dichotomous response of Malassezia-infected macrophages to Malassezia pachydermatis and Malassezia furfur. Medical Mycology, 2019, DOI: https://doi.org/10.1093/mmy/myy104
    • Moura, M.L.C., Alvares-Saraiva, A.M., Pérez, E.C., Xavier, J.G., Spadacci-Morena, D.D., Moyses, C.R.S., Rocha, P.R.D., Lallo, M.A. Cyclophosphamide Treatment Mimics Sub-Lethal Infections with Encephalitozoon intestinalis in Immunocompromised Individuals. Frontiers in Microbiology, 2019, DOI: https://doi.org/10.3389/fmicb.2019.02205
    • Neves, J. J. A.; Paulino, A.; Vieira, R. G.; Nishida, E.; Coutinho, S.D.A. The presence of dermatophytes in infected pets and their household environment. Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2018, DOI: https://doi.org/10.1590/1678-4162-9660
    • Neves, J.J.A.; Francelino, M.; Silva, F.G.L.; Baptista, L.C (orientados de Iniciação Científica).; Bueno, M.G.; Catao-Dias, J.L.; Molina, C.; Kierulff, M. C.; Pissinatti, A.; Coutinho, S.D.A. Survey of Malassezia sp and dermatophytes in the cutaneous microbiome of free-ranging golden-headed lion tamarins (Leontopithecus chrysomelas - Kuhl, 1820). Journal of Medical Primatology, 2017, DOI: https://doi.org/10.1111/jmp.12259
    • Neves, J.J.A.; Alvarez J.M.; Molinari, A.R.; Pasquetti, M.; Coutinho, S.D., Peano, A. Molecular typing of isolates of Microsporum canis collected in Brazil. Journal of Fungi, 2019;
    • Pereira, A., Alvares-Saraiva, A.M., Konno, F.T.C., Spadacci-Morena, D.D., Pérez, E.C., Mariano, M., Lallo, M.A. B-1 cell-mediated modulation of M1 macrophage profile can ameliorate microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. PloS Neglected Tropical Diseases, 2019, DOI: https://doi.org/10.1371/journal.pntd.0007674
    • Santos, D.L., Alvares-Saraiva, A.M., Xavier, J.G., Spadacci-Morena, D.D., Peres, G.B., Rocha, P.R.D., Pérez, E.C., Lallo, M.A. B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis. Microbres and Infection, 2018, DOI: https://doi.org/10.1016/j.micinf.2017.11.004
    • Santos, M.F., Soares, M.A.M., Lallo, M.A., Barros-Batesti, D.M., Lima-Neto, S., Spadacci-Morena, D.D. Morphodifferentiation of Gené’s organ in engorged Amblyomma sculptum Berlese, 1888 female ticks (Acari: Ixodidae). Ticks and Tick-Borne Diseases, 2018, DOI: https://doi.org/10.1016/j.ttbdis.2018.01.004
    • Silva, N.H.; Paciencia, M.L.B.; Frana, S.A.; Diaz, I.E.C.; Suffredini, I.B. Antibacterial activity of essential oils from leaves of Iryanthera ulei Warb. (Myristicaceae): a temporal analysis perspective. Journal of Essential Oil-Bearing Plants, 2020, DOI: https://doi.org/10.1080/0972060X.2020.1820910
    • Teixeira, R.J., Eiras, JC, Spadacci-Morena, D.D., Xavier, J.G., Lallo, M.A. Infecção das brânquias de tilápia do Nilo (Oreochromis niloticus) por Myxosporea. Pesquisa Veterinária Brasileira, 2018, DOI: https://doi.org/10.1590/1678-5150-pvb-4859