Corpo Docente

Area of Activity

Veterinarian with projects related to the pathogenic and immunological aspects of opportunistic and emerging infectious diseases such as Giardiasis, Cryptosporidiosis and Microsporidiosis.
Epidemiological approach focused on One Health, integrating issues of animal, human and environmental health in relation to opportunistic diseases.
Has clinical projects involving frequent gastrointestinal infections in small animal clinics.
Evaluates morphofunctional alterations with ticks of importance in animal husbandry and in the transmission of zoonoses.
Review Editor and Guest Editor of international scientific journals.

More information

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Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations

Research Groups

• Clininfec - Clinic and Infectious Veterinary Diseases
• Biology of Cellular Differentiation and Transformation: Modulation by Endogenous and Exogenous Factors
• Experimental and Environmental Neuropsychopharmacology
  

Disciplines

• Project Seminars I
• Project Seminars II
• Epidemiology Applied to the Environment and Health
• Special Topics Applied to Education

Featured Publications

• Codeceira JF, Alvares-Saraiva AM, Hurtado ECP, Spadacci-Morena DD, Coutinho SD, Lallo MA. Heat-killed Malassezia pachydermatis suspension modulates the activity of macrophages challenged with Encephalitozoon cuniculi. Journal of Medical Mycology. 2023 Mar;33(1):101338. doi: 10.1016/j.mycmed.2022.101338.
• Dalboni LC, Alvares Saraiva AM, Konno FT de C, Perez EC, Codeceira JF, Spadacci-Morena DD, et al. Encephalitozoon cuniculi takes advantage of efferocytosis to evade the immune response. PLOS ONE. 2021 Mar 5;16(3):e0247658. doi: 10.1371/journal.pone.0247658.
• de Oliveira CGN, Perez EC, Alvares-Saraiva AM, Lallo MA. CD8 T lymphocytes from B-1 cell-deficient mice down-regulates fungicidal activity of macrophages challenged with E. Cuniculi. Immunobiology. 2024 Jul;229(4):152827. doi: 10.1016/j.imbio.2024.152827.
• Figuerêdo Moreira I, Marcelino Alvares-Saraiva A, Cristina Pérez E, Guilherme Xavier J, Denelle Spadacci-Morena D, Silva de Araújo R, et al. Opportunistic pneumonia caused by E. cuniculi in mice immunosuppressed with cyclophosphamide. Immunobiology. 2022 May;227(3):152194. doi: 10.1016/j.imbio.2022.152194.
• Hidifira AM, Alvares-Saraiva AM, Perez EC, Spadacci-Morena DD, de Araujo RS, Lallo MA. Increased susceptibility to encephalitozoonosis associated with mixed Th1/Th2 profile and M1/M2 profile in mice immunosuppressed with cyclophosphamide. Experimental Parasitology. 2023 Nov;254:108606. doi: 10.1016/j.exppara.2023.108606.
• Moysés CRS, Alvares-Saraiva AM, Perez EC, Spadacci-Morena DD, Vidôto da Costa LF, Xavier JG, et al. Mice with genetic and induced B-cell deficiency as a model for disseminated encephalitozoonosis. Comparative Immunology, Microbiology and Infectious Diseases. 2022 Feb;81:101742. doi 10.1016/j.cimid.2021.101742.
• Romano F, Lallo MA. Efficacy of a single dose of nitazoxanide in dogs naturally infected with Giardia duodenalis. Research in Veterinary Science. 2023 Jun;159:252–6. doi: 10.1016/j.rvsc.2023.04.022.
• ROMANO F, XAVIER JG, de ARAÚJO RS, COUTINHO SD, LALLO MA. Successful use of albendazole and fenbendazole therapy in a cat with persistent diarrhea due Enterocytozoon bieneusi. Journal of Veterinary Medical Science. 2022;84(6):22–0045. doi: 10.1292/jvms.22-0045.

Area of Activity

Pharmacist, Prof. Dr. Ivana Suffredini conducts multidisciplinary research in the areas of Pharmacognosy, Pharmacology and Toxicology of Medicinal Plants, Chemistry of Natural Products, Microbiology and Ethnoveterinary Medicine. Her main focus is the “Evaluation of antitumor, antimicrobial and antioxidant activity, general toxicity and behavioral changes of plant extracts and essential oils”, applied to Veterinary and Human Medicine.
Through the study of plant extracts from Brazilian plants from the Amazon Rainforest, the Atlantic Forest and plants from Antarctica, such as bryophytes, she seeks to understand the use of phytotherapeutics and active natural compounds in the context of One Health in in vitro and in vivo models. Prof. Suffredini also works as Review Editor and Guest Editor in international scientific journals.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations

Research Groups

• Biological, Pharmacological and Toxicological Activities of Natural Products
• Drug Therapy Applied to Health Sciences

Disciplines

• Veterinary and Human Ethnopharmacology and One Health
• Bioethics and Scientific Methodology
• Special Topics Applied to Education
• Project Seminars
• Scientific Week Seminars

Featured Publications

• Alves C dos S, Frias H v., Kirsten TB, Cordeiro F, Bernardi MM, Suffredini IB. Luffa operculata fruit aqueous extract induces motor impairments, anxiety-like behavior, and testis damage in rats. Journal of Ethnopharmacology. 2018 Aug;222:52–60. doi: 10.1016/j.jep.2018.04.044.
• Frias H v., Alves C dos S, Flório JC, Bondan EF, Bonamin L v., Coelho CP, et al. Vertical exposition to Luffa operculata extract deregulates behavior and hypothalamus neurotransmitters in juvenile rats. Journal of Ethnopharmacology. 2021 Jan;264:113265. doi: 10.1016/j.jep.2020.113265.
• Martins ER, Díaz IEC, Paciencia MLB, Fana SA, Morais D, Eberlin MN, et al. Interference of Seasonal Variation on the Antimicrobial and Cytotoxic Activities of the Essential Oils from the Leaves of Iryanthera polyneura in the Amazon Rain Forest. Chemistry & Biodiversity. 2019 Oct 11;16(10). doi: 10.1002/cbdv.201900374.
• Martins ER, Díaz IEC, Paciencia MLB, Frana SA, Marques MOM, de Morais DR, et al. Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach. PLOS ONE. 2019 Nov 12;14(11):e0224406. doi: 10.1371/journal.pone.0224406.
• Nicolau ALA, Peres GB, de Souza Silva J, Nunes SH, Fortes TML, Suffredini IB. Pilot project. Resveratrol intake by physical active and sedentary older adult women and blood pressure. Experimental Gerontology. 2022 Sep;166:111883. doi: 10.1016/j.exger.2022.111883.
• Suffredini I, Paciencia M, Díaz IngritEC, Frana S, Bernardi M. Mice behavioral phenotype changes after administration of Anani (Symphonia globulifera, clusiaceae), an alternative Latin American and African medicine. Pharmacognosy Magazine. 2017;13(52):617. doi: 10.4103/pm.pm_168_17.
• Suffredini IB, Alves C dos S, Frias HV, Bonamin LV, Bondan EF, Coelho C de P, et al. The gestational exposure to Luffa operculata and a late stressor in young Wistar rats induce sex-specific behavioral, inflammatory, and stress hormone responses. Brazilian Journal of Pharmaceutical Sciences. 2024;60. doi: 10.1590/s2175-97902024e23474.
• Suffredini IB, Silva J de S, Frana SA, Pinto KC, Bento KCD, Rudiger EC, et al. Screening Amazon rainforest plant extracts for antimicrobial activity: a 15-year commitment to the Brazilian biodiversity. Frontiers in Antibiotics. 2023 Jul 12;2. doi: 10.3389/frabi.2023.1122400.

Area of Activity

Veterinarian with experience in Genetics, especially Molecular Genetics of Viruses.
Her research includes:

• Microbiology (emphasis on bacteria and viruses)
• Vaccine development
• Laboratory diagnosis for infectious diseases

She works on vaccine development projects for swine in collaboration with Iowa State University. Prof. Castro is also a Review Editor and Guest Editor for international scientific journals.

More information

Currículo Lattes

Google Scholar

ORCID

ResearchGate

LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations

Research Groups

• Clininfec - Veterinary Clinic and Infectious Diseases

Disciplines

• Epidemiology Applied to the Environment and Health (collaborator)
• Basic Epigenetics I (collaborator)
• Emergence and Reemergence of Infectious Diseases in the Globalized World (responsible)
• Special Topics Applied to Education

Featured Publications
Book Chapter

• Karuppannan AK, de Castro AMMG, Opriessnig T. Recent Advances in Veterinary Diagnostic Virology. In: Advanced Techniques in Diagnostic Microbiology. 3rd ed. Cham: Springer International Publishing; 2018. p. 317–44. doi: 10.1007/978-3-319-95111-9_14.

Articles

• Cortez A, Metorima CS, Miyagi SAT, Sousa AO, Peyser AV, Castro AMMG, et al. High genetic diversity of hepatitis E virus in swine in São Paulo State, Brazil. Brazilian Archives of Veterinary Medicine and Animal Science. 2021 Oct;73(5):1237–42. doi: 10.1590/1678-4162-12203.
• Opriessnig T, Karuppannan AK, Castro AMMG, Xiao CT. Porcine circoviruses: current status, knowledge gaps and challenges. Virus Research. 2020 Sep;286:198044. doi: 10.1016/j.virusres.2020.198044.
• Opriessnig T, Castro AMMG, Karuppanan AK, Gauger PC, Halbur PG, Matzinger SR, et al. A Porcine circovirus type 2b (PCV2b)-based experimental vaccine is effective in the PCV2b-Mycoplasma hyopneumoniae coinfection pig model. Vaccinate. 2019 Oct;37(44):6688–95. doi: 10.1016/j.vaccine.2019.09.029.
• Opriessnig T, Gauger PC, Gerber PF, Castro AMMG, Shen H, Murphy L, et al. Comparison of the efficacy of a commercial inactivated influenza A/H1N1/pdm09 virus (pH1N1) vaccine and two experimental M2e-based vaccines against pH1N1 challenge in the growing pig model. PLOS ONE. 2018 Jan 30;13(1):e0191739. doi: 10.1371/journal.pone.0191739.

Area of Activity

Biologist with research analyzing the regulatory role of B-1 cells in diabetes models and their interactions with effector T lymphocytes and regulatory T cells in the context of autoimmunity and metabolic diseases.
She evaluates the regulatory role of B-1 lymphocytes in an experimental model of diabetes and the capacity of this lymphocyte to produce insulin, as well as the potential of cell therapy for the treatment of type 1 diabetes, with metabolic reprogramming of B-1 cells in vitro.
She studies the prevalence of diabetes mellitus among adolescents and the management of lifestyle habits (exercise and diet) to improve the health parameters of this population.
She also collaborates in several studies with an emphasis on the parasite-host relationship, immune response in infections and immune response in tumor models.
She works as Review Editor and Guest Editor of international scientific journals.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations
• Special Topics Applied to Education

Research Groups

• Biology of Cellular Differentiation and Transformation: Modulation by Endogenous and Exogenous Factors
• Clininfec - Veterinary Clinic and Infectious Diseases

Disciplines

• From Cell Culture to Cell Therapy: Fundamentals and Advances
• Special Topics Applied to Education
• Scientific Dissemination

Featured Publications

• Alvares‐Saraiva AM, Novo MCT, de Oliveira VC, Maricato JT, Lopes JD, Popi AF, et al. B‐1 cells produce insulin and abrogate experimental streptozotocin‐induced diabetes. European Journal of Immunology. 2015 May 17;45(5):1452–61. doi: 10.1002/eji.201445409.
• da Costa LFV, Alvares-Saraiva AM, Dell’Armelina Rocha PR, Spadacci-Morena DD, Perez EC, Mariano M, et al. B-1 cell decreases susceptibility to encephalitozoonosis in mice. Immunobiology. 2017 Feb;222(2):218–27. doi: 10.1016/j.imbio.2016.09.018.
• Francisco Neto A, Dell’Armelina Rocha PR, Perez EC, Xavier JG, Peres GB, Spadacci-Morena DD, et al. Diabetes mellitus increases the susceptibility to encephalitozoonosis in mice. PLOS ONE. 2017 Nov 1;12(11):e0186954. doi: 10.1371/journal.pone.0186954.
• Langanke dos Santos D, Alvares-Saraiva AM, Xavier JG, Spadacci-Morena DD, Peres GB, Dell’Armelina Rocha PR, et al. B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis. Microbes and Infection. 2018 Mar;20(3):196–204. doi: 10.1016/j.micinf.2017.11.004.
• Pereira A, Alvares-Saraiva AM, Konno FT de C, Spadacci-Morena DD, Perez EC, Mariano M, et al. B-1 cell-mediated modulation of M1 macrophage profile ameliorates microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. PLOS Neglected Tropical Diseases. 2019 Sep 19;13(9):e0007674. doi: 10.1371/journal.pntd.0007674.

Area of Activity

Veterinarian with extensive experience in morphology and pathophysiology, with a focus on neurobiology. His main research topics include:

• Glial cells (astrocytes, oligodendrocytes and microglia)
• Demyelination and remyelination
• Chemobrain (post-chemotherapy cognitive dysfunction)
• Neuroinflammation
• Neurodegenerative diseases
• Infectious and parasitic diseases of the nervous system

Develops projects in oncology and veterinary clinic for small and large animals. He also works as Review Editor and Guest Editor in international scientific journals.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations
• Special Topics Applied to Education

Research Groups

• Experimental and Environmental Neuropsychopharmacology

Disciplines

• Research Methods in Neuropathology
• Topics in Animal and Comparative Circulatory Pathophysiology

Featured Publications

• Baliellas DEM, Barros MP, Vardaris C v., Guariroba M, Poppe SC, Martins MF, et al. Propentofylline Improves Thiol-Based Antioxidant Defenses and Limits Lipid Peroxidation following Gliotoxic Injury in the Rat Brainstem. Biomedicines. 2023 Jun 7;11(6):1652. doi: 10.3390/biomedicines11061652.
• Cardoso CV, de Barros MP, Bachi ALL, Bernardi MM, Kirsten TB, de Fátima Monteiro Martins M, et al. Chemobrain in rats: Behavioral, morphological, oxidative and inflammatory effects of doxorubicin administration. Behavioural Brain Research. 2020 Jan;378:112233. doi: 10.1016/j.bbr.2019.112233.
• Cavalcante de Queiroz A, Barbosa Suffredini I, Dimas de Oliveira J, de Souza Silva J, Fernandes Bondan E. A feasible in vitro method to evaluate bacterial infiltration in three implant-abutment connection systems. Journal of Oral Research. 2024 Jan 1;13(1):26–36. doi: 10.17126/joralres.2024.003.
• de Oliveira AS, Convento MB, Razvickas CV, Castino B, Leme AM, da Silva Luiz R, et al. The Nephroprotective Effects of the Allogeneic Transplantation with Mesenchymal Stromal Cells Were Potentiated by ω3 Stimulating Up-Regulation of the PPAR-γ. Pharmaceuticals. 2023 Oct 18;16(10):1484. doi: 10.3390/ph16101484.
• Góes LG, Vilarino FL, Oba E, Bondan EF. Review of the literature on corpus luteum insufficiency in women (2015–2020) and in domestic animals (1980–2020). Clínica e Investigación en Ginecología y Obstetricia. 2022 Apr;49(2):100724. doi: 10.1016/j.gine.2021.100724.
• Martins-Júnior JL, Bernardi MM, Bondan EF. Propentofylline treatment on open field behavior in rats with focal ethidium bromide-induced demyelination in the ventral surface of the brainstem. Life Sciences. 2016 Mar;148:132–8. doi: 10.1016/j.lfs.2016.02.028.
• Molina J, Joaquim A, Bonamin LV, Martins M de FM, Kirsten TB, Cardoso CV, et al. Reduced astrocytic expression of GFAP in the offspring of female rats that received hypercaloric diet. Nutritional Neuroscience. 2020 Jun 2;23(6):411–21. doi: 10.1080/1028415X.2018.1512783.
• Moretti RL, Dias EN, Kiel SG, Augusto MCM, Rodrigues PS, Sampaio ACS, et al. Behavioral and morphological effects of resveratrol and curcumin in rats submitted to doxorubicin-induced cognitive impairment. Research in Veterinary Science. 2021 Nov;140:242–50. doi: 10.1016/j.rvsc.2021.09.009.
• Nascimento BPP, Bocco BMLC, Fernandes GW, Fonseca TL, McAninch EA, Cardoso C v, et al. Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice. Endocrinology. 2018 Aug 1;159(8):3090–104. doi: 10.1210/en.2018-00146.
• Ogassawara TB, Joaquim A, Coelho CP, Bernardi MM, Teodorov E, Martins MFM, et al. Food deprivation in F0 generation and hypercaloric diet in F1 generation reduce F2 generation astrogliosis in several brain areas after immune challenge. International Journal of Developmental Neuroscience. 2018 Feb 19;64(1):29–37. doi: 10.1016/j.ijdevneu.2017.06.003.
• Siqueira RF de, Hansen VS, Martins M de FM, Leal ML do R, Bondan EF. West Nile Fever Virus Infection in Horses in São Paulo State, Brazil. Acta Scientiae Veterinariae. 2022 Jan 1;50. doi: 10.22456/1679-9216.117796.
• Suffredini IB, Alves C dos S, Frias HV, Bonamin LV, Bondan EF, Coelho C de P, et al. The gestational exposure to Luffa operculata and a late stressor in young Wistar rats induce sex-specific behavioral, inflammatory, and stress hormone responses. Brazilian Journal of Pharmaceutical Sciences. 2024;60. doi: 10.1590/s2175-97902024e23474.
• Vazi EPG, Holanda F, Santos NA, Cardoso CV, Martins MFM, Bondan EF. Short-term systemic methotrexate administration in rats induces astrogliosis and microgliosis. Research in Veterinary Science. 2021 Sep;138:39–48. doi: 10.1016/j.rvsc.2021.05.020.

Area of Activity

Biomedical scientist with experience in Immunology, Cellular and Molecular Biology and Microbiology, with emphasis on: tumor immunology, tumor microenvironment, oncological homeopathy, extracellular vesicles and immune response against yeasts and parasites.
Develops projects that investigate the interactions between tumor cells and components of the immune system in the development and progression of cancer in in vivo and in vitro models of melanoma and breast cancer.
Also researches cellular and molecular events triggered by homeopathic preparations of Phytolacca decandra and Viscum album as potential antitumor agents or for integrative use in cancer treatment, both in the veterinary and human fields.
Works as Review Editor and Guest Editor of international scientific journals.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations

Research Groups

• Biology of Cellular Differentiation and Transformation: Modulation by Endogenous and Exogenous Factors
• Clininfec - Veterinary Clinical and Infectious Diseases

Disciplines

• Biological Techniques in Research
• Immunoregulation
• Special Topics Applied to Education

Featured Publications

• Almeida EB, Silva KPH, Paixão V, Amaral JB do, Rossi M, Xavier-Navarro RA, et al. A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment. International Journal of Molecular Sciences. 2019 Aug 1;20(15):3765. doi: 10.3390/ijms20153765.
• Carvalho JR, Nascimento ESM, Xavier JG, Banamin LV, Hurtado ECP. Papel do Microambiente Tumoral no Desenvolvimento do Melanoma. Veterinária Notícias. 2015 Sep 21;21(2). doi: 10.14393/VTv21n2a2015.29673.
• Colhado Rodrigues BL, Lallo MA, Perez EC. The Controversial Role of Autophagy in Tumor Development: A Systematic Review. Immunological Investigations. 2020 May 18;49(4):386–96. doi: 10.1080/08820139.2019.1682600.
• Perez EC, Xander P, Laurindo MFL, Novaes e Brito RR, Vivanco BC, Mortara RA, et al. The axis IL-10/claudin-10 is implicated in the modulation of aggressiveness of melanoma cells by B-1 lymphocytes. PLOS ONE. 2017 Nov 16;12(11):e0187333. doi: 10.1371/journal.pone.0187333.
• Pérez EC, Machado J, Aliperti F, Freymüller E, Mariano M, Lopes JD. B‐1 lymphocytes increase metastatic behavior of melanoma cells through the extracellular signal‐regulated kinase pathway. Cancer Science. 2008 May 28;99(5):920–8. doi: 10.1111/j.1349-7006.2008.00776.x.
• Staquicini FI, Tandle A, Libutti SK, Sun J, Zigler M, Bar-Eli M, et al. A Subset of Host B Lymphocytes Controls Melanoma Metastasis through a Melanoma Cell Adhesion Molecule/MUC18-Dependent Interaction: Evidence from Mice and Humans. Cancer Research. 2008 Oct 15;68(20):8419–28. doi: 10.1158/0008-5472.CAN-08-1242.

Area of Activity

Graduated in Biological Sciences - Medical Modality from the Federal University of São Paulo (2009), Master (2012) and Doctor of Sciences (2016) from the Postgraduate Program in Molecular Biology of the same university.
He has experience in:
a) Academic research in the areas of Biochemistry and Molecular Biology, with an emphasis on glycoconjugates;
b) Teaching, teaching from Pre-University to Postgraduate courses and also acting in coordination positions;
c) Collaborative management and business administration.
Works as Review Editor and Guest Editor of international scientific journals.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Ecotoxicology and Therapeutic Innovations

Research Groups

• Clininfec - Veterinary Clinic and Infectious Diseases

Disciplines

• Statistics Applied to Research I
• Statistics Applied to Research II

Featured Publications

• Andrade SS, Sumikawa JT, Castro ED, Batista FP, Paredes-Gamero E, Oliveira LC, et al. Interface between breast cancer cells and the tumor microenvironment using platelet-rich plasma to promote tumor angiogenesis - influence of platelets and fibrin bundles on the behavior of breast tumor cells. Oncotarget. 2017 Mar 7;8(10):16851–74. doi: 10.18632/oncotarget.15170.
• de Santana FR, Dalboni LC, Nascimento KF, Konno FT, Alvares-Saraiva AM, Correia MSF, et al. High dilutions of antimony modulate cytokines production and macrophage – Leishmania (L.) amazonensis interaction in vitro. Cytokine. 2017 Apr;92:33–47. doi: 10.1016/j.cyto.2017.01.004.
• Peres GB, Schor N, Michelacci YM. Impact of high glucose and AGEs on cultured kidney-derived cells. Effects on cell viability, lysosomal enzymes and effectors of cell signaling pathways. Biochimie. 2017 Apr;135:137–48. doi: 10.1016/j.biochi.2017.02.004.
• Peres GB, Juliano MA, Simões MJ, Michelacci YM. Lysosomal enzymes are decreased in the kidney of diabetic rats. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013 Jan;1832(1):85–95. doi: 10.1016/j.bbadis.2012.09.011.
• Toricelli M, Melo FH, Peres GB, Silva DC, Jasiulionis MG. Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. Molecular Cancer. 2013 Dec 25;12(1):1095. doi: 10.1186/1476-4598-12-22.

Area of Activity

Veterinarian with projects in Animal and Comparative Pathology, working mainly on the following topics: comparative oncology; use of morphological, immunological and molecular techniques as diagnostic, prognostic and predictive tools in animal neoplasias; pathology of lymphohematopoietic organs; veterinary dermatopathology and ichthyopathology.
Review Editor and Guest Editor of international scientific journals.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations

Research Groups

• Biology of Cellular Differentiation and Transformation: Modulation by Endogenous and Exogenous Factors
• Structural and Functional Ecology of Ecosystems

Disciplines

• Topics in Tumor Biology
• Special Topics Applied to Education

Featured Publications

• Araújo B de L, Serantoni Moyses CR, Spadacci-Morena DD, Xavier JG, Lallo MA. White spots amidst the gold: ultrastructural and histological aspects of the chronic inflammatory response of goldfish with ichthyophthiriasis. Journal of Comparative Pathology. 2024 May;211:21–5. doi: 10.1016/j.jcpa.2024.04.003.
• Barra CN, Macedo BM, Cadrobbi KG, Pulz LH, Huete GC, Kleeb SR, et al. Apoptotic intrinsic pathway proteins predict survival in canine cutaneous mast cell tumours. Veterinary and Comparative Oncology. 2018 Mar 13;16(1). doi: 10.1111/vco.12330.
• Daniel J, Barra CN, Pulz LH, Kleeb SR, Xavier JG, Catão‐Dias JL, et al. Intratumoral collagen index predicts mortality and survival in canine cutaneous mast cell tumours. Veterinary Dermatology. 2019 Apr 28;30(2):162. doi: 10.1111/vde.12726.
• de Nardi AB, Costa MT, Amorim RL, Vasconcelos RO, Dagli MLZ, Rocha NS, et al. Brazilian consensus for the diagnosis, treatment and prognosis of cutaneous mast cell tumors in dogs. INVESTIGAÇÃO. 2018 Feb 2;17(1). doi: 10.26843/investigacao.v17i1.1837.
• Joselevitch JA, Vargas THM, Pulz LH, Cadrobbi KG, Huete GC, Nishiya AT, et al. High lysyl oxidase expression is an indicator of poor prognosis in dogs with cutaneous mast cell tumours. Veterinary and Comparative Oncology. 2023 Sep 25;21(3):401–5. doi: 10.1111/vco.12898.
• Joselevitch JA, Barra CN, Vargas THM, Pulz LH, Nishiya AT, Kleeb SR, et al. Nanog Expression and Proliferation Indices in Canine Cutaneous Mast Cell Tumors. Veterinary Pathology. 2018 Nov 19;55(6):849–52. Doi: 10.1177/0300985818789470.
• Moyses CRS, Spadacci-Morena DD, Xavier JG, Antonucci AM, Lallo MA. Ectocommensal and ectoparasites in goldfish Carassius auratus (Linnaeus, 1758) in farmed in the State of São Paulo. Revista Brasileira de Parasitologia Veterinária. 2015 Sep;24(3):283–9. doi: 10.1590/S1984-29612015054.
• Nishiya AT, Nagamine MK, Fonseca IIM da, Miraldo AC, Villar Scattone N, Guerra JL, et al. Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas. Toxins. 2020 Mar 2;12(3):157. doi: 10.3390/toxins12030157.
• Silva JG da, Salzedas BA, Xavier JG. Emprego da histopatologia no diagnóstico diferencial de lesões nodulares esplênicas em cães submetidos à esplenectomia. REVISTA FOCO. 2024 Oct 21;17(10):e6566. doi: 10.54751/revistafoco.v17n10-101.
• Teixeira RJ, Eiras JC, Spadacci-Morena DD, Xavier JG, Lallo MA. Infecção das brânquias de tilápia do Nilo (Oreochromis niloticus) por Myxosporea. Pesquisa Veterinária Brasileira. 2018 Jun;38(6):1085–90. doi: 10.1590/1678-5150-pvb-4859.
• Vargas THM, Barra CN, Pulz LH, Huete GC, Cadrobbi KG, Nishiya AT, et al. Galectin-3 immunolabelling correlates with BCL2 expression in canine cutaneous mast cell tumours. Acta Veterinaria Hungarica. 2021 Jul 31;69(2):169–74. doi: 10.1556/004.2021.00019.
• Xavier JG, Favero ME, Vinolo MAR, Rogero MM, Dagli MLZ, Arana-Chavez VE, et al. Protein-energy malnutrition alters histological and ultrastructural characteristics of the bone marrow and decreases haematopoiesis in adult mice. Histology and histopathology. 2007 Jun;22(6):651–60. doi: 10.14670/HH-22.651.
• Yasumaru CC, Xavier JG, Strefezzi RDF, Salles-Gomes COM. Intratumoral T-Lymphocyte Subsets in Canine Oral Melanoma and Their Association With Clinical and Histopathological Parameters. Veterinary Pathology. 2021 May 25;58(3):491–502. doi: 10.1177/0300985821999321.

Area of Activity

Veterinarian with projects related to the effects of high dynamized dilutions on living systems and their correlations with physical-chemical aspects of such preparations. The focus of the research is to understand the mechanisms of action involved and explore all possible uses, both in veterinary clinics (through homeopathic medicines) and in food production, recovery of degraded environments and vector control in wild environments (through dynamized inputs for agricultural use).
Main projects: homeopathy and environmental health; correlations between physical-chemical aspects of high dilutions and their biological and clinical effects.
President (2002-2008) and Vice-President (2008-2014) of GIRI (Groupe International de Recherche sur l’Infinitésimal).
Deputy Editor of the journal Homeopathy – The Journal of the Faculty of Homeopathy – London since 2015.
Editor-in-Chief of the journal International Journal of High Dilution Research (IJHDR) since 2019.
Member of the core group of researchers associated with the World Water Lab since 2022.
Member of the Permanent Commission of Homeopathy of CRMV-SP since 2023.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations

Research Groups

• Experimental and Environmental Neuropsychopharmacology
• Biology of Cellular Differentiation and Transformation: Modulation by Endogenous and Exogenous Factors

Disciplines

• Susceptibility and Complexity in the One Health Approach
• Water and Biological Self-Organization
• International Workshop on Veterinary Homeopathy (TBC)

Featured Publications
Organized Book:

• Aleixo D, Baumgartner S, Ciuppa L, Paiva JP de, Homsani F, Araujo SM, et al. Transdisciplinarity and Translationality in High Dilution Research. 1st ed. Vol. 1. 2019.

Articles Published in Scientific Journals:

• Aparicio ACC, de Oliveira LHS, Silva JS, Coelho CP, Pinheiro SR, Souza MF, et al. Interaction between Solvatochromic Dyes and Water Sampled from a Natural Source Treated with High Dilutions of Phosphorus. Homeopathy. 2020 Aug 12;109(03):126–32. doi: 10.1055/s-0039-3400255.
• de Medeiros NSS, Pinto AAG, Frana S, Souza MF, Suffredini IB, Cartwright SJ, et al. Solvatochromic Dyes Track a Homeopathic Preparation through Water-Stream Systems in a Program to Control Tick Infestation at a Wild Animal Rehabilitation Center in Brazil. Homeopathy. 2024 Sep 9. doi: 10.1055/s-0044-1787783.
• de Santana FR, Dalboni LC, Nascimento KF, Konno FT, Alvares-Saraiva AM, Correia MSF, et al. High dilutions of antimony modulate cytokines production and macrophage – Leishmania (L.) amazonensis interaction in vitro. Cytokine. 2017 Apr;92:33–47. doi: 10.1016/j.cyto.2017.01.004.
• Endler PC, Thieves K, Reich C, Matthiessen P, Bonamin L, Scherr C, et al. Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study. Homeopathy. 2010 Jan;99(1):25–36. doi: 10.1016/j.cyto.2017.01.004.
• Mohammad SN, Pinto AAG, Silva RA da, Suffredini IB, Tournier AL, Cartwright SJ, et al. Environmental Homeopathy: Homeopathic Potencies Regulate the Toxicity and Growth of Raphidiopsis raciborskii (cyanobacteria) and can be Tracked Physico-Chemically. Part 1: Biological Results. Homeopathy. 2024 May 6. doi: 10.1055/s-0044-1780526.
• Mohammad SN, Pinto AAG, Silva RA da, Suffredini IB, Tournier AL, Cartwright SJ, et al. Environmental Homeopathy: Homeopathic Potencies Regulate the Growth and Toxicity of Raphidiopsis raciborskii (cyanobacteria) and Can be Tracked Physico-Chemically. Part 2: Physico-chemical Results. Homeopathy. 2024 May 6. doi: 10.1055/s-0044-1780527.
• Nagai MYD de O, Mohammad SN, Pinto AAG, Coimbra EN, Peres GB, Suffredini IB, et al. Highly Diluted Glyphosate Mitigates Its Effects on Artemia salina: Physicochemical Implications. International Journal of Molecular Sciences. 2023 May 30;24(11):9478. doi: 10.3390/ijms24119478.
• Pinto AAG, Nagai MY de O, Coimbra EN, Mohammad SN, Silva JS, von Ancken A, et al. Bioresilience to Mercury Chloride of the Brine Shrimp Artemia Salina after Treatment with Homeopathic Mercurius Corrosivus. Homeopathy. 2021 Nov 2;110(04):244–55. doi: 10.1055/s-0041-1729562.
• Tournier AL, Bonamin L v., Buchheim-Schmidt S, Cartwright S, Dombrowsky C, Doesburg P, et al. Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias—the PrePoP guidelines. Journal of Integrative Medicine. 2024 Sep;22(5):533–44. doi: 10.1016/j.joim.2024.06.005.

Area of Activity

Biologist, graduated from the University of São Paulo, works in the areas of Pharmacology, Toxicology and Neuroscience.
Her research is related to Developmental Toxicology and Neuroscience and Behavior.
She studies the changes promoted in the perinatal period by immune system modulators, obesity, medications, heavy metals, pesticides and endocrine disruptors, with a view to investigating behavioral, endocrine, epigenetic and molecular aspects and the development of animal models of mental disorders.
She is the leader-coordinator of the CNPq Research Group on Experimental and Environmental Neuropsychopharmacology and a member of the Plastics Working Group of the Brazilian Academy of Sciences (ABC).
She is a Review Editor and Guest Editor of international scientific journals.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations

Research Groups

• Experimental and Environmental Neuropsychopharmacology

Disciplines

• Developmental and Reproductive Toxicology
• Bioethics and Methodology of Scientific Research
• Special Topics Applied to Education

Featured Publications

• Bernardi MM, Macrini DJ, Rodrigues P da S, Kirsten TB, Chaves-Kirsten GP, Florio JC, et al. Overweight induced by hypernutrition in juvenile rats dysregulates the central monoamines in the adult age. Psychology & Neuroscience. 2021 Mar;14(1):34–48. doi: 10.1037/pne0000204.
• Cordeiro F, Ceglio F, Galvão N, Bonamin L, Bondan EF, Kirsten TB, et al. Does a therapeutical dose of ivermectin impairs testicular homeostasis of rats via excessive apoptosis? Veterinaria Italiana. 2023. doi: https://doi.org// 10.12834/Vetit.2692.19722.2.
• de Oliveira-Higa MA, da Silva Rodrigues P, Sampaio ACS, de Camargo Coque A, Kirsten TB, Massironi SMG, et al. The dopaminergic D1 receptor modulates the hyperactivity of Bapa mutant mice. Behavioural Brain Research. 2023 Aug;452:114562. doi: 10.1016/j.bbr.2023.114562.
• Gonçalves FB, Garcia-Gomes MSA, Silva-Sampaio AC, Kirsten TB, Bondan EF, Sandini TM, et al. Progressive tremor and motor impairment in seizure-prone mutant tremor mice are associated with neurotransmitter dysfunction. Behavioural Brain Research. 2023 Apr;443:114329. doi: 10.1016/j.bbr.2023.114329.
• Medeiros L da S, Rodrigues P da S, Santos DNL, Silva-Sampaio AC, Kirsten TB, Suffredini IB, et al. Prenatal restraint stress downregulates the hypothalamic kisspeptidergic system transcripts genes, reduces the estrogen plasma levels, delayed the onset of puberty, and reduced the sexual behavior intensity in female rats. Physiology & Behavior. 2023 Mar;260:114055. doi: 10.1016/j.physbeh.2022.114055.
• Rodrigues P da S, Sampaio ACS, Silva ÉP da, Suffredini IB, Bondan EF, Bernardi MM, et al. Sexual motivation and performance in sexual naïve and experienced rats treated with ivermectin: an ultrasonic vocalization study / Motivação e desempenho sexual em ratos com e sem experiência sexual tratados com ivermectina: um estudo da vocalização ultrassônica. Portal Reginal da BVS. 2023 Mar; doi: https://doi.org/10.11606/issn.1678-4456.bjvras.2023.198441.
• Schatzer CA de F, Milazzotto MP, Júnior AR dos S, Cerchiaro G, Bernardi MM, Teodorov E. Microencapsulation of sunscreen reduces toxicity of its components to A. salina: Biochemical, behavioral and morphological studies. Ecotoxicology and Environmental Safety. 2024 Aug;281. doi: 10.1016/j.ecoenv.2024.116586.

Area of Activity

Biologist with projects related to the involvement of epigenetic mechanisms applied to the transcriptional control of multifactorial diseases of human and veterinary interest.
A basic approach focused on the search for biomarkers of interest for One Health and better elucidation of the molecular mechanisms related to neuroprotection.
Has experimental projects involving animal models related to neuroinflammation and the application of epigenetic analyses in animal health.
Hers main focus is the characterization of the neuroprotective effect and the involvement of DNA methylation in transcriptional control.
Review Editor and Guest Editor of international scientific journals.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations

Research Groups

• Experimental and Environmental Neuropsychopharmacology

Disciplines

• Basic Epigenetics
• Special Topics Applied to Education

Featured Publications

• Assis RIF, Feltran G da S, Silva MES, Palma IC do R, Rovai ES, Miranda TB de, et al. Non-coding RNAs repressive role in post-transcriptional processing of RUNX2 during the acquisition of the osteogenic phenotype of periodontal ligament mesenchymal stem cells. Developmental Biology. 2021 Feb;470:37–48. doi: 10.1016/j.ydbio.2020.10.012.
• Carvalho LB, dos Santos Sanna PL, dos Santos Afonso CC, Bondan EF, da Silva Feltran G, Ferreira MR, et al. MicroRNA biogenesis machinery activation and lncRNA and REST overexpression as neuroprotective responses to fight inflammation in the hippocampus. Journal of Neuroimmunology. 2023 Sep;382:578149. doi: 10.1016/j.jneuroim.2023.578149.
• Costa MR, dos Santos AYI, de Miranda TB, Aires R, de Camargo Coque A, Hurtado ECP, et al. Impact of neuroinflammation on epigenetic transcriptional control of Sonic Hedgehog members in the central nervous system. Brain Research. 2023 Jan;1799:148180. doi: 10.1016/j.brainres.2022.148180.
• da Silva RA, da S. Feltran G, da C. Fernandes CJ, Zambuzzi WF. Osteogenic gene markers are epigenetically reprogrammed during contractile-to-calcifying vascular smooth muscle cell phenotype transition. Cellular Signalling. 2020 Feb;66:109458. doi: 10.1016/j.cellsig.2019.109458.
• da Silva RA, Fernandes CJ da C, Feltran G da S, Gomes AM, de Camargo Andrade AF, Andia DC, et al. Laminar shear stress-provoked cytoskeletal changes are mediated by epigenetic reprogramming of TIMP1 in human primary smooth muscle cells. Journal of Cellular Physiology. 2019 May 21;234(5):6382–96. doi: 10.1002/jcp.27374.
• Lemes dos Santos Sanna P, Bernardes Carvalho L, Cristina dos Santos Afonso C, de Carvalho K, Aires R, Souza J, et al. Adora2A downregulation promotes caffeine neuroprotective effect against LPS-induced neuroinflammation in the hippocampus. Brain Research. 2024 Jun;1833:148866. doi: 10.1016/j.brainres.2024.148866.
• Patricia da Silva E, da Silva Feltran G, Alexandre Alcântara dos Santos S, Cardoso de Oliveira R, Assis RIF, Antônio Justulin Junior L, et al. Hyperglycemic microenvironment compromises the homeostasis of communication between the bone-brain axis by the epigenetic repression of the osteocalcin receptor, Gpr158 in the hippocampus. Brain Research. 2023 Mar;1803:148234.  doi: 10.1016/j.brainres.2023.148234.
• Pinto TS, Feltran G da Silva, Fernandes CJ da C, de Camargo Andrade AF, Coque A de C, Silva SL, et al. Epigenetic changes in shear‐stressed endothelial cells. Cell Biology International. 2024 May 29;48(5):665–81. doi: 10.1002/cbin.12138.
• Remor AP, da Silva RA, de Matos FJ, Glaser V, de Paula Martins R, Ghisoni K, et al. Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation. Molecular Neurobiology. 2019 Mar 14;56(3):1539–57. doi: 10.1007/s12035-018-1175-9.

Area of Activity

Biologist with a postgraduate degree in veterinary medicine and leader of the Psychoneuroimmunology Laboratory and the CNPq Research Group: Experimental and Environmental Neuropsychopharmacology.
He has experimental projects in the areas of Experimental Models of Behavioral and Psychiatric Disorders and Developmental Studies, topics for which he was awarded the 'CAPES Thesis Award' and the 'USP Outstanding Thesis Award'.
He also works in the area of ​​Ecotoxicology, with emphasis on studies with microplastics.
He has experience in other scientific/therapeutic areas: Environmental Pathology, Mental Health, Neuroscience, Animal Behavior, Animal Models and Perinatal Studies.
Review Editor and Guest Editor of international scientific journals.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines

• Integrated and Translational Pathology
• Ecotoxicology and Therapeutic Innovations

Research Groups

• Experimental and Environmental Neuropsychopharmacology

Disciplines

• Experimental Models in Laboratory Animal Behavior
• Special Topics Applied to Education
• Referratas in Environmental and Experimental Pathology
• Scientific Dissemination

Featured Publications

• Chiminazzo LLW, Kirsten TB. Psychomotor and neurofunctional aspects after COVID-19. Acta Neuropsychiatrica. 2023 Oct 6;35(5):292–302. doi: 10.1017/neu.2023.2.
• Galvão NA, Cordeiro F, Bernardi MM, Kirsten TB. Ivermectin prevents stress-induced testicular damage in juvenile rats. Tissue and Cell. 2024 Feb;86:102292. doi: 10.1016/j.tice.2023.102292.
• Kirsten TB, Silva EP, Biondi TF, Rodrigues PS, Cardoso C v., Massironi SMG, et al. Bate palmas mutant mice as a model of Kabuki syndrome: Higher susceptibility to infections and vocalization impairments? Journal of Neuroscience Research. 2022 Jul;100(7):1438–51. doi: 10.1002/jnr.25050.
• Kirsten TB, Cabral D, Galvão MC, Monteiro R, Bondan EF, Bernardi MM. Zinc, but not paracetamol, prevents depressive-like behavior and sickness behavior, and inhibits interferon-gamma and astrogliosis in rats. Brain, Behavior, and Immunity. 2020 Jul;87:489–97. doi: 10.1016/j.bbi.2020.01.019.
• Kirsten TB, Casarin RC, Bernardi MM, Felicio LF. Pioglitazone abolishes autistic-like behaviors via the IL-6 pathway. PLOS ONE. 2018 May 23;13(5):e0197060. Doi: 10.1371/journal.pone.0197060.
• Kirsten TB, Chaves-Kirsten GP, Bernardes S, Scavone C, Sarkis JE, Bernardi MM, et al. Lipopolysaccharide Exposure Induces Maternal Hypozincemia, and Prenatal Zinc Treatment Prevents Autistic-Like Behaviors and Disturbances in the Striatal Dopaminergic and mTOR Systems of Offspring. PLOS ONE. 2015 Jul 28;10(7):e0134565. doi: 10.1371/journal.pone.0134565.
• Leme E, Silva EP, Rodrigues PS, Silva IR, Martins MFM, Bondan EF, et al. Billings reservoir water used for human consumption presents microbiological contaminants and induces both behavior impairments and astrogliosis in zebrafish. Ecotoxicology and Environmental Safety. 2018 Oct;161:364–73. doi: 10.1016/j.ecoenv.2018.06.009.
• Parisi DP, Santos SAR, Cabral D, Queiroz-Hazarbassanov N, Flório JC, Bernardi MM, et al. Therapeutical doses of ivermectin and its association with stress disrupt motor and social behaviors of juvenile rats and serotonergic and dopaminergic systems. Research in Veterinary Science. 2019 Jun;124:149–57. doi: 10.1016/j.rvsc.2019.03.009.